Detailed information of TA system TA033232

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2359320..2359504
• Replicon: chromosome
• Accession: NZ_AP020311
• Organism: Staphylococcus aureus strain KUH140013

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: F6Y13_RS11845
• Protein ID: WP_000482650.1
• Coordinates: 2359320..2359427 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2359444..2359504 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6Y13_RS11820	2354683..2355156	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
F6Y13_RS11825	2355279..2356490	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
F6Y13_RS11830	2356672..2357331	-	660	WP_000831298.1	membrane protein	-
F6Y13_RS11835	2357391..2358533	-	1143	WP_001176862.1	glycerate kinase	-
F6Y13_RS11840	2358801..2359187	+	387	WP_000779358.1	flippase GtxA	-
F6Y13_RS11845	2359320..2359427	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2359444..2359504	-	61	-	-	Antitoxin
F6Y13_RS11850	2360055..2361818	+	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
F6Y13_RS11855	2361843..2363576	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
F6Y13_RS11860	2363807..2363974	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T33232 WP_000482650.1 NZ_AP020311:2359320-2359427 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T33232 NZ_AP020311:2359320-2359427 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT33232 NZ_AP020311:c2359504-2359444 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin