33217

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 300485..300998 Replicon chromosome
Accession NZ_AP019865
Organism Rickettsia heilongjiangensis strain Sendai-58

Toxin (Protein)


Gene name yoeB Uniprot ID H6QL72
Locus tag GOZ28_RS01660 Protein ID WP_012152537.1
Coordinates 300738..300998 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0F3RGJ3
Locus tag GOZ28_RS01655 Protein ID WP_014013992.1
Coordinates 300485..300727 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ28_RS01635 295512..297281 - 1770 WP_014013988.1 ABC transporter ATP-binding protein/permease -
GOZ28_RS01640 297462..297731 + 270 WP_014013989.1 DUF2671 domain-containing protein -
GOZ28_RS01645 297886..299256 + 1371 WP_014013990.1 cytochrome ubiquinol oxidase subunit I -
GOZ28_RS01650 299264..300283 + 1020 WP_014013991.1 cytochrome d ubiquinol oxidase subunit II -
GOZ28_RS01655 300485..300727 + 243 WP_014013992.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GOZ28_RS01660 300738..300998 + 261 WP_012152537.1 Txe/YoeB family addiction module toxin Toxin
GOZ28_RS01665 300991..301839 + 849 WP_014013993.1 glycosyltransferase family 2 protein -
GOZ28_RS01670 301916..303154 + 1239 WP_014013994.1 insulinase family protein -
GOZ28_RS01675 303308..304018 + 711 WP_014013995.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
GOZ28_RS01680 304247..305833 + 1587 WP_155980674.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10314.10 Da        Isoelectric Point: 9.9572

>T33217 WP_012152537.1 NZ_AP019865:300738-300998 [Rickettsia heilongjiangensis]
MYIIRYTTQAQKDAKKIVQAGLKNKVEVLLNIVSTDPWKIYPPYEKLVGDFSGCYSRRINIQHRLVYEVYKQEKVVKILR
MYTHYE

Download         Length: 261 bp

>T33217 NZ_AP019865:300738-300998 [Rickettsia heilongjiangensis]
ATGTATATAATTCGTTATACTACACAAGCACAAAAAGATGCTAAGAAAATAGTGCAAGCCGGTTTAAAGAATAAAGTAGA
AGTTTTATTAAACATAGTTAGTACTGATCCTTGGAAAATTTACCCTCCATATGAAAAGCTCGTTGGTGACTTTAGCGGTT
GTTATTCAAGAAGAATTAATATTCAACATAGGTTGGTTTATGAAGTTTACAAACAAGAAAAAGTTGTAAAAATTCTTAGA
ATGTATACGCATTATGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9405.83 Da        Isoelectric Point: 7.1617

>AT33217 WP_014013992.1 NZ_AP019865:300485-300727 [Rickettsia heilongjiangensis]
MEIYNTSEARSKLYKLIDYVSDVHKPVYIKGKRNNVVIISEEDYRNMEETLYLLSIPNMHKSLIEGRAEPIAKCSDKLNW

Download         Length: 243 bp

>AT33217 NZ_AP019865:300485-300727 [Rickettsia heilongjiangensis]
ATGGAAATATATAATACAAGCGAAGCAAGAAGTAAGCTTTATAAACTTATAGATTATGTTTCTGATGTACACAAACCTGT
TTATATTAAAGGTAAAAGAAATAATGTAGTTATAATTTCAGAAGAAGATTATCGTAATATGGAAGAAACTTTATATTTAT
TATCTATTCCAAATATGCATAAGTCTCTAATTGAAGGACGCGCAGAGCCTATAGCAAAGTGTAGCGATAAATTAAATTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H6QL72

Antitoxin

Source ID Structure
AlphaFold DB A0A0F3RGJ3

References