Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1181321..1181835 Replicon chromosome
Accession NZ_AP019827
Organism Leptotrichia shahii strain JCM16776

Toxin (Protein)


Gene name yoeB Uniprot ID A0A510JNH8
Locus tag F1564_RS05540 Protein ID WP_018449908.1
Coordinates 1181321..1181578 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A510JNI1
Locus tag F1564_RS05545 Protein ID WP_018449907.1
Coordinates 1181578..1181835 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1564_RS05520 1176990..1177646 - 657 WP_018449913.1 HAD family hydrolase -
F1564_RS05525 1177686..1177907 - 222 WP_018449912.1 DUF896 domain-containing protein -
F1564_RS05530 1178435..1179808 - 1374 WP_018449911.1 FAD-dependent oxidoreductase -
F1564_RS05535 1180110..1181069 - 960 WP_018449909.1 hypothetical protein -
F1564_RS05540 1181321..1181578 - 258 WP_018449908.1 Txe/YoeB family addiction module toxin Toxin
F1564_RS05545 1181578..1181835 - 258 WP_018449907.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
F1564_RS05550 1182158..1183546 + 1389 WP_018449906.1 MATE family efflux transporter -
F1564_RS05555 1183775..1184752 - 978 WP_197737474.1 Gfo/Idh/MocA family oxidoreductase -
F1564_RS05560 1185528..1186439 + 912 WP_018449903.1 DUF4431 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-66)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10240.83 Da        Isoelectric Point: 9.9281

>T33154 WP_018449908.1 NZ_AP019827:c1181578-1181321 [Leptotrichia shahii]
MNLIWNNEAWEEYLQWQKQDKKIVKKINEIIKDIKRNGNEGIGKPEPLKHELSGYWSRRITDKHRFIYKLTETSIVVIAC
ANHYK

Download         Length: 258 bp

>T33154 NZ_AP019827:c1181578-1181321 [Leptotrichia shahii]
ATGAATCTGATTTGGAATAATGAGGCTTGGGAAGAATATCTCCAATGGCAGAAACAGGATAAAAAAATAGTCAAAAAAAT
AAATGAAATAATAAAAGACATCAAAAGAAACGGCAATGAAGGAATAGGAAAGCCTGAGCCTTTAAAGCATGAACTGAGTG
GATATTGGAGCAGAAGAATTACAGATAAGCACAGGTTTATATATAAACTGACAGAAACAAGTATAGTAGTTATCGCCTGT
GCAAATCATTATAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10175.48 Da        Isoelectric Point: 4.6909

>AT33154 WP_018449907.1 NZ_AP019827:c1181835-1181578 [Leptotrichia shahii]
MIATNYSNVRNNLKKYCDKATDDYETVIITRKNDKNVVLMSEEEYNNLMENFYIMSNKKYYNELLKRKEEVEAGNVQIHD
IIEVE

Download         Length: 258 bp

>AT33154 NZ_AP019827:c1181835-1181578 [Leptotrichia shahii]
ATGATAGCTACAAATTATTCAAATGTAAGAAATAATTTAAAAAAATATTGTGATAAGGCAACTGATGATTATGAAACAGT
CATTATAACAAGAAAAAACGATAAAAATGTGGTGCTGATGAGTGAAGAGGAGTATAACAATTTGATGGAAAATTTTTACA
TCATGTCAAATAAGAAATATTATAATGAACTGTTAAAAAGAAAAGAAGAAGTAGAGGCGGGAAATGTACAAATACATGAT
ATAATTGAGGTGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510JNH8

Antitoxin

Source ID Structure
AlphaFold DB A0A510JNI1

References