Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1080797..1081298 Replicon chromosome
Accession NZ_AP019827
Organism Leptotrichia shahii strain JCM16776

Toxin (Protein)


Gene name yoeB Uniprot ID A0A510JQT9
Locus tag F1564_RS05060 Protein ID WP_018450009.1
Coordinates 1081044..1081298 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A510JN96
Locus tag F1564_RS05055 Protein ID WP_018450010.1
Coordinates 1080797..1081051 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1564_RS05035 1076797..1077399 - 603 WP_149201906.1 3'-5' exonuclease -
F1564_RS05040 1077476..1079272 - 1797 WP_018450013.1 translation elongation factor 4 -
F1564_RS05045 1079624..1080289 - 666 WP_018450012.1 YdcF family protein -
F1564_RS05050 1080364..1080648 - 285 WP_018450011.1 virulence associated protein VapD -
F1564_RS05055 1080797..1081051 + 255 WP_018450010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F1564_RS05060 1081044..1081298 + 255 WP_018450009.1 Txe/YoeB family addiction module toxin Toxin
F1564_RS05065 1081429..1083324 - 1896 WP_018450008.1 ABC transporter ATP-binding protein/permease -
F1564_RS05070 1083324..1085063 - 1740 WP_018450007.1 ABC transporter ATP-binding protein/permease -
F1564_RS05075 1085212..1085949 - 738 WP_018450006.1 esterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-58)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9990.40 Da        Isoelectric Point: 9.3929

>T33153 WP_018450009.1 NZ_AP019827:1081044-1081298 [Leptotrichia shahii]
MNKLWTDDGWADYLYWQSQDKKTLKRINELIKDIERNGVLNGIGKPEALKYRKGFSRRIDETNRLVYAIDENGVLWIISC
RGHY

Download         Length: 255 bp

>T33153 NZ_AP019827:1081044-1081298 [Leptotrichia shahii]
ATGAATAAATTATGGACTGATGATGGCTGGGCAGATTATTTATATTGGCAATCTCAAGATAAAAAAACTTTAAAAAGGAT
TAACGAACTCATAAAAGATATTGAAAGAAATGGAGTATTGAATGGAATAGGCAAACCTGAAGCTTTGAAATATAGAAAAG
GATTTAGTCGAAGAATTGACGAAACTAACAGGCTTGTCTATGCTATTGATGAAAATGGAGTTTTATGGATAATTTCTTGT
AGAGGACATTATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9683.02 Da        Isoelectric Point: 5.1297

>AT33153 WP_018450010.1 NZ_AP019827:1080797-1081051 [Leptotrichia shahii]
MLVVSFSTMRNNLKSYCDKAVKENEDVIVTRKNEENVVLINLEKYNQFLKAVQNAEYLAKIDRGFSQMKSGKGQVHDLIE
VDDE

Download         Length: 255 bp

>AT33153 NZ_AP019827:1080797-1081051 [Leptotrichia shahii]
ATGTTAGTTGTAAGTTTTTCAACTATGAGAAATAATTTAAAAAGTTATTGTGATAAAGCAGTGAAAGAAAATGAAGATGT
AATTGTAACAAGAAAAAATGAAGAAAATGTAGTTTTAATAAATCTTGAAAAATATAATCAATTTTTGAAAGCAGTCCAAA
ATGCTGAATATCTTGCAAAAATAGATAGAGGGTTTTCTCAGATGAAAAGTGGAAAAGGACAAGTTCATGATTTAATCGAG
GTCGACGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510JQT9

Antitoxin

Source ID Structure
AlphaFold DB A0A510JN96

References