Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 15275..15932 | Replicon | plasmid pN069_1 |
| Accession | NZ_AP019818 | ||
| Organism | Enterobacter hormaechei subsp. hoffmannii strain OIPH-N069 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | G7Y81_RS22395 | Protein ID | WP_000270043.1 |
| Coordinates | 15582..15932 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | G7Y81_RS22390 | Protein ID | WP_000124640.1 |
| Coordinates | 15275..15577 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G7Y81_RS22340 | 10493..11305 | + | 813 | WP_151819882.1 | 3'-5' exonuclease | - |
| G7Y81_RS22345 | 11299..11745 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| G7Y81_RS22350 | 11742..12260 | + | 519 | WP_011872844.1 | hypothetical protein | - |
| G7Y81_RS22355 | 12260..12490 | + | 231 | WP_020833601.1 | hypothetical protein | - |
| G7Y81_RS22360 | 12477..13334 | + | 858 | WP_001167033.1 | hypothetical protein | - |
| G7Y81_RS22370 | 13565..14092 | + | 528 | WP_011872875.1 | thermonuclease family protein | - |
| G7Y81_RS22375 | 14146..14583 | + | 438 | WP_151819883.1 | ATP-binding protein | - |
| G7Y81_RS22380 | 14593..14865 | + | 273 | WP_151819884.1 | HU family DNA-binding protein | - |
| G7Y81_RS22385 | 14954..15247 | + | 294 | WP_020833606.1 | chromosome segregation protein ParM | - |
| G7Y81_RS22390 | 15275..15577 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| G7Y81_RS22395 | 15582..15932 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| G7Y81_RS22400 | 16095..16643 | + | 549 | WP_151819885.1 | transcriptional regulator | - |
| G7Y81_RS22410 | 16984..17178 | + | 195 | WP_151819886.1 | hypothetical protein | - |
| G7Y81_RS22415 | 17302..17565 | + | 264 | WP_151819887.1 | hypothetical protein | - |
| G7Y81_RS22420 | 17791..18147 | - | 357 | WP_020833609.1 | hypothetical protein | - |
| G7Y81_RS22425 | 18244..18732 | + | 489 | WP_164597181.1 | DUF1643 domain-containing protein | - |
| G7Y81_RS22430 | 18735..19232 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| G7Y81_RS22440 | 20091..20573 | + | 483 | Protein_32 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | fosG / blaCTX-M-2 / aadA2 / aac(6')-Iae / qacE / sul1 / blaKHM-1 | - | 1..136816 | 136816 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T33142 WP_000270043.1 NZ_AP019818:c15932-15582 [Enterobacter hormaechei subsp. hoffmannii]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T33142 NZ_AP019818:c15932-15582 [Enterobacter hormaechei subsp. hoffmannii]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT33142 WP_000124640.1 NZ_AP019818:c15577-15275 [Enterobacter hormaechei subsp. hoffmannii]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT33142 NZ_AP019818:c15577-15275 [Enterobacter hormaechei subsp. hoffmannii]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCTGACGGCACCCACTACGGTTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCTGACGGCACCCACTACGGTTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|