Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 89681..90354 Replicon plasmid pHC11
Accession NZ_AP019802
Organism Thermus thermophilus strain HC11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag TthHC11_RS10935 Protein ID WP_011174422.1
Coordinates 89938..90354 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag TthHC11_RS10930 Protein ID WP_041443928.1
Coordinates 89681..89941 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TthHC11_RS10920 86144..87352 - 1209 WP_143591991.1 LamG domain-containing protein -
TthHC11_RS10925 89124..89468 + 345 Protein_92 hypothetical protein -
TthHC11_RS10930 89681..89941 + 261 WP_041443928.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
TthHC11_RS10935 89938..90354 + 417 WP_011174422.1 type II toxin-antitoxin system VapC family toxin Toxin
TthHC11_RS11870 90589..90726 - 138 WP_162467451.1 hypothetical protein -
TthHC11_RS10950 90887..92110 - 1224 WP_143591897.1 ATP-binding protein -
TthHC11_RS11875 92215..92766 + 552 WP_172967316.1 hypothetical protein -
TthHC11_RS10960 92869..93284 - 416 Protein_98 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..258759 258759
flank IS/Tn - - 92955..93200 245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-71)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15274.81 Da        Isoelectric Point: 8.6238

>T33079 WP_011174422.1 NZ_AP019802:89938-90354 [Thermus thermophilus]
MSYLLDTNVVSEAAKQRPHPKVLAWLSETPLGQAYLSALTLGELVQGVVRAPEARKPGLERWLEGLKQRFAGRILPLDAE
VMETWGLLTGEALREGRPLSPLDALLAATALRHGLVLVTRNVAHFRGLPLRLLNPWEE

Download         Length: 417 bp

>T33079 NZ_AP019802:89938-90354 [Thermus thermophilus]
TTGAGCTACCTCCTGGACACCAACGTGGTGTCCGAGGCCGCCAAGCAAAGGCCTCATCCCAAGGTTCTGGCCTGGCTCTC
AGAGACCCCTCTGGGACAGGCCTACCTCTCCGCCCTCACCCTGGGGGAACTGGTCCAGGGGGTGGTCCGGGCTCCCGAGG
CCCGGAAGCCGGGGCTGGAGCGGTGGCTGGAGGGGCTCAAGCAGCGCTTTGCGGGGAGGATCCTGCCTCTGGACGCGGAG
GTCATGGAAACTTGGGGTCTCCTCACAGGGGAGGCCCTCCGGGAGGGACGTCCCCTTTCCCCTCTGGATGCCCTGCTCGC
CGCCACCGCTCTCCGCCACGGCCTCGTCCTGGTCACCCGGAACGTGGCCCATTTCCGGGGTCTCCCCCTACGGTTGCTCA
ATCCCTGGGAGGAATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9818.05 Da        Isoelectric Point: 4.9126

>AT33079 WP_041443928.1 NZ_AP019802:89681-89941 [Thermus thermophilus]
VGRVWQLQEAKARFSEVVERALKGEPQTVTRRGRPVVVVVDWATYTRLRGEEASLWEALRAPEPLSEEEAETLFTREAAG
YREVGF

Download         Length: 261 bp

>AT33079 NZ_AP019802:89681-89941 [Thermus thermophilus]
GTGGGACGGGTGTGGCAACTCCAAGAAGCCAAAGCCCGCTTCTCCGAAGTGGTGGAGCGGGCTCTTAAGGGTGAACCCCA
GACCGTTACCCGGCGGGGGCGGCCCGTGGTGGTGGTGGTGGACTGGGCTACCTACACCCGCCTCCGGGGGGAGGAGGCCT
CCCTTTGGGAGGCTCTCCGTGCCCCTGAGCCCCTTTCCGAGGAGGAGGCGGAAACCCTTTTCACCCGGGAGGCTGCGGGG
TACCGGGAGGTGGGGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References