Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2621387..2621910 Replicon chromosome
Accession NZ_AP019751
Organism Staphylococcus aureus strain JRA307

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag FPG46_RS13510 Protein ID WP_000074048.1
Coordinates 2621387..2621653 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag FPG46_RS13515 Protein ID WP_000587616.1
Coordinates 2621653..2621910 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPG46_RS13490 2616693..2617880 - 1188 WP_000026194.1 MFS transporter -
FPG46_RS13495 2618276..2619052 - 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
FPG46_RS13500 2619045..2619707 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
FPG46_RS13505 2619955..2621031 - 1077 WP_001076671.1 M42 family metallopeptidase -
FPG46_RS13510 2621387..2621653 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
FPG46_RS13515 2621653..2621910 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FPG46_RS13525 2622269..2622724 + 456 WP_000732082.1 DUF1307 domain-containing protein -
FPG46_RS13530 2622892..2624469 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
FPG46_RS13535 2624665..2625414 + 750 WP_000072445.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T32986 WP_000074048.1 NZ_AP019751:c2621653-2621387 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T32986 NZ_AP019751:c2621653-2621387 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT32986 WP_000587616.1 NZ_AP019751:c2621910-2621653 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT32986 NZ_AP019751:c2621910-2621653 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References