Detailed information of TA system TA032976

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2120776..2121074
• Replicon: chromosome
• Accession: NZ_AP019751
• Organism: Staphylococcus aureus strain JRA307

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: FPG46_RS10830
• Protein ID: WP_144079026.1
• Coordinates: 2120898..2121074 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2120776..2120869 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPG46_RS10805	2117106..2117942	-	837	WP_000675478.1	hypothetical protein	-
FPG46_RS10810	2118394..2119488	-	1095	WP_144078987.1	hypothetical protein	-
FPG46_RS10815	2119676..2120430	-	755	Protein_2036	CHAP domain-containing protein	-
FPG46_RS10820	2120442..2120696	-	255	WP_144078988.1	phage holin	-
FPG46_RS10825	2120747..2120842	+	96	Protein_2038	hypothetical protein	-
-	2120776..2120869	+	94	NuclAT_1	-	Antitoxin
-	2120776..2120869	+	94	NuclAT_1	-	Antitoxin
-	2120776..2120869	+	94	NuclAT_1	-	Antitoxin
-	2120776..2120869	+	94	NuclAT_1	-	Antitoxin
FPG46_RS10830	2120898..2121074	-	177	WP_144079026.1	putative holin-like toxin	Toxin
FPG46_RS10835	2121227..2121526	-	300	WP_000466774.1	DUF2951 family protein	-
FPG46_RS10840	2121572..2121736	-	165	WP_000916021.1	XkdX family protein	-
FPG46_RS10845	2121729..2122118	-	390	WP_015978057.1	DUF2977 domain-containing protein	-
FPG46_RS10850	2122118..2123584	-	1467	WP_000067131.1	BppU family phage baseplate upper protein	-
FPG46_RS10855	2123584..2125494	-	1911	WP_000429552.1	hypothetical protein	-
FPG46_RS10860	2125510..2125800	-	291	WP_000179860.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb	2115773..2167774	52001

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6881.51 Da
• Isoelectric Point: 10.6777

>T32976 WP_144079026.1 NZ_AP019751:c2121074-2120898 [Staphylococcus aureus]
MDRWWLSEYKEVVPMMALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T32976 NZ_AP019751:c2121074-2120898 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGATGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 94 bp

>AT32976 NZ_AP019751:2120776-2120869 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCACAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTTTTCATAGAAAAA
TTATAAAAATAACC

Structures

Antitoxin