Detailed information of TA system TA032969

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 417905..418243
• Replicon: chromosome
• Accession: NZ_AP019751
• Organism: Staphylococcus aureus strain JRA307

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: FPG46_RS02090
• Protein ID: WP_072357969.1
• Coordinates: 417905..418081 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	418069..418243 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPG46_RS02070	413140..416925	+	3786	WP_144078919.1	hypothetical protein	-
FPG46_RS02075	416915..417067	+	153	WP_001153681.1	hypothetical protein	-
FPG46_RS02080	417114..417401	+	288	WP_001040261.1	hypothetical protein	-
FPG46_RS02085	417459..417755	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
FPG46_RS02090	417905..418081	+	177	WP_072357969.1	putative holin-like toxin	Toxin
-	418069..418243	-	175	-	-	Antitoxin
FPG46_RS02100	418293..418547	+	255	WP_045178738.1	phage holin	-
FPG46_RS02105	418559..419314	+	756	WP_111761863.1	CHAP domain-containing protein	-
FPG46_RS02110	419753..420688	+	936	WP_111761864.1	bi-component leukocidin LukPQ subunit P	-
FPG46_RS02115	420690..421670	+	981	WP_086037611.1	bi-component leukocidin LukPQ subunit Q	-
FPG46_RS02120	422111..422455	+	345	WP_106096712.1	complement inhibitor SCIN family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	379806..422455	42649

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T32969 WP_072357969.1 NZ_AP019751:417905-418081 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T32969 NZ_AP019751:417905-418081 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT32969 NZ_AP019751:c418243-418069 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACACGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin