Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2106939..2108211 Replicon chromosome
Accession NZ_AP019739
Organism Alistipes communis strain 6CPBBH3

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag FME94_RS08810 Protein ID WP_141418982.1
Coordinates 2107270..2108211 (+) Length 314 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag FME94_RS08805 Protein ID WP_141418981.1
Coordinates 2106939..2107268 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FME94_RS08790 2102400..2103830 - 1431 WP_141418978.1 type I restriction-modification system subunit M -
FME94_RS08795 2103837..2106551 - 2715 WP_141418979.1 DEAD/DEAH box helicase family protein -
FME94_RS08800 2106727..2106942 + 216 WP_141418980.1 helix-turn-helix transcriptional regulator -
FME94_RS08805 2106939..2107268 + 330 WP_141418981.1 HipA N-terminal domain-containing protein Antitoxin
FME94_RS08810 2107270..2108211 + 942 WP_141418982.1 HipA domain-containing protein Toxin
FME94_RS08815 2108636..2109514 + 879 Protein_1728 helix-turn-helix domain-containing protein -
FME94_RS08820 2109693..2110737 - 1045 Protein_1729 virulence RhuM family protein -
FME94_RS08825 2110746..2112302 - 1557 Protein_1730 type I restriction-modification system subunit M -
FME94_RS08830 2112304..2112965 - 662 Protein_1731 C39 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(55-283)

Antitoxin

HipA, N-terminal subdomain 1

(5-101)


Sequences

Toxin        


Download         Length: 314 a.a.        Molecular weight: 35938.61 Da        Isoelectric Point: 8.3069

>T32964 WP_141418982.1 NZ_AP019739:2107270-2108211 [Alistipes communis]
MERCLYCYKELADGERDFHKSCSKKIFGTPQVPLLPYTRANIAELAREVIRSQTTLTGVQAKLSLDIAKEGKGTPERFTI
VGLWGRYILKPQTEHYPHLPELEDLTMHMAEAVKMQVVPHSLVRFADGELCYITRRIDRGPHGEKYPMEDLCQLSERLTE
HKYKGSYEQIAKTILRYSSAPKLDAVNFWEQVLFSWLTGNADMHLKNFSLYSLNPGVYGLTPAYDLLSTALVLPEDTEEL
ALTLNGRKRKLRRSDFVQAMTASGMDEKVIDNLFKKFIKAIPKWGEWIDVSFLPEEMKGKYKALIAERIKQLT

Download         Length: 942 bp

>T32964 NZ_AP019739:2107270-2108211 [Alistipes communis]
ATGGAGCGTTGTTTATATTGTTACAAAGAATTAGCCGACGGCGAGCGGGATTTCCACAAATCCTGCTCCAAGAAGATTTT
CGGCACTCCCCAAGTACCTTTGCTCCCCTACACGCGCGCCAATATCGCGGAACTTGCCCGCGAGGTAATCCGCAGCCAAA
CGACGCTGACCGGAGTGCAGGCAAAGTTGTCGCTCGACATTGCCAAAGAGGGCAAAGGCACCCCGGAACGCTTTACGATC
GTCGGGCTGTGGGGCCGCTATATCCTCAAACCGCAGACCGAACATTATCCGCATTTGCCGGAACTGGAAGATTTGACCAT
GCACATGGCCGAAGCCGTGAAGATGCAGGTAGTCCCCCACTCGCTCGTCCGCTTTGCCGACGGGGAGTTGTGCTACATCA
CACGCCGCATCGACCGAGGGCCTCACGGCGAAAAATATCCGATGGAAGACCTCTGTCAGCTCTCCGAACGACTGACAGAA
CACAAATACAAAGGTTCCTACGAGCAGATTGCCAAAACAATTCTGCGCTATTCTTCCGCCCCGAAACTGGATGCCGTCAA
TTTCTGGGAGCAAGTGTTGTTCTCTTGGCTCACGGGCAATGCCGACATGCACCTCAAAAATTTTTCGCTGTATAGCCTGA
ATCCGGGTGTTTATGGGCTGACACCGGCTTATGACCTGCTATCGACAGCGCTCGTTTTACCCGAAGACACCGAGGAATTG
GCACTGACGCTGAACGGCCGCAAACGCAAGCTCCGCCGCAGCGATTTCGTGCAGGCAATGACGGCTTCGGGCATGGACGA
AAAGGTAATCGACAACCTGTTCAAGAAATTCATCAAAGCCATTCCGAAATGGGGCGAGTGGATCGACGTTTCGTTTCTGC
CCGAAGAAATGAAAGGCAAATACAAAGCGCTTATCGCAGAAAGAATCAAACAACTAACATAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12532.40 Da        Isoelectric Point: 4.3509

>AT32964 WP_141418981.1 NZ_AP019739:2106939-2107268 [Alistipes communis]
MKQAAIYLYNRKAGLLTEDETGYTFRYDADYLRLPDAEAVSFTLPLTEQVYRDKVLFPFFDGLIPEGWLLDIAEKSWKID
NRDRMSLLLACCKDCIGAVSVIPIESKEE

Download         Length: 330 bp

>AT32964 NZ_AP019739:2106939-2107268 [Alistipes communis]
ATGAAACAGGCTGCCATCTATCTCTACAACCGCAAGGCGGGGCTTTTGACCGAGGATGAAACCGGTTACACGTTCCGCTA
CGATGCCGACTATCTCCGCCTGCCCGATGCCGAAGCGGTCAGTTTCACGCTGCCGCTTACGGAGCAAGTCTATCGCGACA
AGGTGCTGTTCCCGTTCTTTGACGGATTGATTCCCGAAGGGTGGCTGCTCGACATTGCCGAAAAGAGCTGGAAAATCGAC
AACCGCGATAGGATGTCGCTGCTTTTGGCCTGCTGCAAAGACTGCATCGGTGCAGTCAGTGTCATACCTATCGAATCAAA
GGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References