Detailed information of TA system TA032953

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 183970..184483
• Replicon: chromosome
• Accession: NZ_AP019720
• Organism: Streptococcus mutans strain NBRC 13955

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: FNL60_RS00975
• Protein ID: WP_002270995.1
• Coordinates: 183970..184224 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FNL60_RS00980
• Protein ID: WP_002270994.1
• Coordinates: 184217..184483 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNL60_RS00940	179846..180262	-	417	WP_002271002.1	conjugal transfer protein	-
FNL60_RS00945	180264..180491	-	228	WP_002280083.1	hypothetical protein	-
FNL60_RS00950	180508..181500	-	993	WP_002280082.1	conjugal transfer protein	-
FNL60_RS00955	181510..182064	-	555	WP_002280081.1	hypothetical protein	-
FNL60_RS00960	182061..182297	-	237	WP_002280080.1	hypothetical protein	-
FNL60_RS00965	182317..182703	-	387	WP_002280079.1	hypothetical protein	-
FNL60_RS00970	182681..183913	-	1233	WP_002280078.1	replication initiation factor domain-containing protein	-
FNL60_RS00975	183970..184224	-	255	WP_002270995.1	Txe/YoeB family addiction module toxin	Toxin
FNL60_RS00980	184217..184483	-	267	WP_002270994.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FNL60_RS00985	184747..186405	-	1659	WP_002280077.1	transposase	-
FNL60_RS00990	186412..186822	-	411	WP_002280076.1	DUF961 family protein	-
FNL60_RS00995	186845..187159	-	315	WP_000406626.1	hypothetical protein	-
FNL60_RS01005	187498..187734	-	237	WP_002280074.1	hypothetical protein	-
FNL60_RS01010	187863..188141	-	279	WP_002280073.1	type II toxin-antitoxin system YafQ family toxin	-
FNL60_RS01015	188142..188414	-	273	WP_002280072.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
FNL60_RS01020	188566..189279	+	714	WP_002280071.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10474.89 Da
• Isoelectric Point: 8.3800

>T32953 WP_002270995.1 NZ_AP019720:c184224-183970 [Streptococcus mutans]
MFNFTEQAWKDYVSWQQEDKKILKRINRLIEDIKRNPFEGIGKPEPLKYRYSGAWSRRITDEHRLVYLVEEDEIYFLSFR
DHYK

Nucleotide

• Length: 255 bp

>T32953 NZ_AP019720:c184224-183970 [Streptococcus mutans]
ATGTTTAACTTTACAGAACAAGCTTGGAAAGATTATGTTTCTTGGCAACAAGAAGATAAAAAGATACTCAAACGTATCAA
TCGTTTAATTGAGGATATCAAACGAAATCCTTTTGAAGGGATTGGAAAACCAGAGCCATTAAAATATCGTTATTCGGGTG
CTTGGTCTCGTAGAATTACAGATGAACACCGATTAGTCTATCTGGTTGAAGAAGATGAAATTTATTTCTTATCCTTTCGA
GACCATTATAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10422.91 Da
• Isoelectric Point: 4.6437

>AT32953 WP_002270994.1 NZ_AP019720:c184483-184217 [Streptococcus mutans]
MEAVVYSNFRNNLKNYMKKVNDEYEPLMVVNKNPDENIVVLSKENWDSIQETIRLMNNDYLSDKVLSGMEQVKQKKVVQR
QLLEVEDV

Nucleotide

• Length: 267 bp

>AT32953 NZ_AP019720:c184483-184217 [Streptococcus mutans]
ATGGAAGCTGTAGTCTATTCAAATTTCAGAAACAACTTAAAGAATTATATGAAAAAAGTCAATGATGAATATGAACCTCT
AATGGTTGTCAATAAAAACCCTGATGAGAATATTGTGGTCTTATCTAAGGAAAACTGGGATAGTATTCAAGAAACCATCC
GCCTAATGAATAACGATTATCTTTCAGACAAGGTTCTATCAGGGATGGAACAAGTTAAACAAAAGAAAGTCGTTCAACGC
CAATTATTAGAGGTGGAAGATGTTTAA