Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 162190..162914 Replicon plasmid pGSH0205-8M-1-1
Accession NZ_AP019670
Organism Raoultella ornithinolytica strain GSH0205-8M-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QMG92_RS26760 Protein ID WP_076752146.1
Coordinates 162190..162501 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QMG92_RS26765 Protein ID WP_076752145.1
Coordinates 162498..162914 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG92_RS26715 (ROGSH02058M1_p11710) 157403..157948 - 546 WP_047365773.1 sigma-70 family RNA polymerase sigma factor -
QMG92_RS26720 (ROGSH02058M1_p11720) 157957..158670 - 714 WP_013087170.1 arsenical resistance protein ArsH -
QMG92_RS26725 (ROGSH02058M1_p11730) 158672..158995 - 324 WP_013087171.1 metalloregulator ArsR/SmtB family transcription factor -
QMG92_RS26730 (ROGSH02058M1_p11740) 159296..159562 + 267 WP_012540086.1 DUF1778 domain-containing protein -
QMG92_RS26735 (ROGSH02058M1_p11750) 159550..160035 + 486 WP_076752153.1 GNAT family N-acetyltransferase -
QMG92_RS26740 (ROGSH02058M1_p11760) 160319..160471 + 153 WP_223526259.1 DUF5431 family protein -
QMG92_RS26745 160416..160535 + 120 WP_223156217.1 type I toxin-antitoxin system Hok family toxin -
QMG92_RS26750 (ROGSH02058M1_p11770) 161394..161720 + 327 WP_076752150.1 hypothetical protein -
QMG92_RS26755 (ROGSH02058M1_p11780) 161828..162040 + 213 WP_076752148.1 hypothetical protein -
QMG92_RS26760 (ROGSH02058M1_p11790) 162190..162501 + 312 WP_076752146.1 type II toxin-antitoxin system HigB family toxin Toxin
QMG92_RS26765 (ROGSH02058M1_p11800) 162498..162914 + 417 WP_076752145.1 helix-turn-helix domain-containing protein Antitoxin
QMG92_RS26770 (ROGSH02058M1_p11820) 163804..164076 + 273 WP_137055850.1 hypothetical protein -
QMG92_RS26775 (ROGSH02058M1_p11830) 164179..164526 + 348 WP_076752140.1 hypothetical protein -
QMG92_RS26780 (ROGSH02058M1_p11840) 164615..164845 + 231 WP_076752138.1 hypothetical protein -
QMG92_RS26785 (ROGSH02058M1_p11850) 164892..165725 + 834 WP_076752137.1 N-6 DNA methylase -
QMG92_RS26790 (ROGSH02058M1_p11860) 165929..166159 - 231 WP_076752135.1 hypothetical protein -
QMG92_RS26795 (ROGSH02058M1_p11870) 166351..166881 + 531 WP_076752134.1 antirestriction protein -
QMG92_RS26800 (ROGSH02058M1_p11880) 166919..167395 - 477 WP_076752132.1 transglycosylase SLT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaNDM-5 - 1..241445 241445


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Antitoxin HigA

(5-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12510.31 Da        Isoelectric Point: 9.9242

>T32860 WP_076752146.1 NZ_AP019670:162190-162501 [Raoultella ornithinolytica]
VHVISRAPFDEAARHYPNDAAAIDDTYRVLKRVVAKKPDELKRYFNSLDRMKYREKWWVIDIGGNNLRMMFFADFERGKI
FVKHITTHAEYDRLTKYYREHKE

Download         Length: 312 bp

>T32860 NZ_AP019670:162190-162501 [Raoultella ornithinolytica]
GTGCATGTTATATCACGAGCCCCTTTTGATGAGGCGGCGAGACACTATCCGAATGATGCAGCGGCCATCGATGACACATA
TCGTGTACTAAAGCGGGTTGTAGCAAAAAAACCGGATGAGCTAAAGCGATACTTTAATAGTCTGGATCGCATGAAATACC
GGGAAAAATGGTGGGTTATCGATATCGGCGGCAATAACCTCAGAATGATGTTTTTTGCTGATTTCGAGCGCGGAAAGATA
TTCGTCAAACACATTACCACCCATGCTGAATATGATCGCTTAACGAAATACTATCGGGAGCACAAAGAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15484.61 Da        Isoelectric Point: 4.4711

>AT32860 WP_076752145.1 NZ_AP019670:162498-162914 [Raoultella ornithinolytica]
MIFSDAIKAANDLASIVPLLGGSSSRKDYEEALKLVEYLLEHDPDSPLVDMLTARIDAWEDNAVEFEEFNTRIEAGKNGV
SLLRVLMQQHGLSQSDFENEIGKKSLVSRILSCERSLTLDHMRALANRFQIPVSMFVD

Download         Length: 417 bp

>AT32860 NZ_AP019670:162498-162914 [Raoultella ornithinolytica]
ATGATTTTTAGCGATGCCATTAAAGCTGCAAATGACCTTGCCAGTATTGTACCCCTGCTGGGTGGCAGCTCGTCCCGCAA
AGATTACGAAGAGGCACTTAAACTCGTTGAATATCTTCTGGAACATGATCCGGACAGCCCGCTGGTTGATATGCTGACTG
CCCGCATCGATGCCTGGGAAGACAACGCGGTGGAATTTGAAGAATTTAATACGCGCATCGAAGCAGGCAAAAACGGTGTC
TCATTGCTGCGGGTTCTTATGCAGCAACATGGGCTTTCACAGTCCGATTTTGAAAACGAGATAGGCAAAAAATCGCTCGT
CAGCCGGATCCTCAGTTGTGAACGCAGTCTGACCCTTGATCACATGCGAGCGCTGGCAAATCGATTTCAAATCCCGGTCT
CGATGTTTGTTGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References