Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 60623..61124 Replicon plasmid pECC18A13-1
Accession NZ_AP019635
Organism Enterobacter sp. 18A13

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag FOY93_RS22885 Protein ID WP_123061045.1
Coordinates 60849..61124 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag FOY93_RS22880 Protein ID WP_103061436.1
Coordinates 60623..60868 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY93_RS22850 55917..56129 + 213 WP_143345843.1 hypothetical protein -
FOY93_RS22855 56172..57002 + 831 WP_143345791.1 type I restriction-modification system subunit M -
FOY93_RS22860 57382..57987 + 606 WP_143345792.1 antirestriction protein -
FOY93_RS22865 57999..58454 - 456 WP_143345793.1 transglycosylase SLT domain-containing protein -
FOY93_RS22870 58922..59296 + 375 WP_143345794.1 relaxosome protein TraM -
FOY93_RS22875 60136..60381 - 246 WP_123061044.1 hypothetical protein -
FOY93_RS22880 60623..60868 + 246 WP_103061436.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOY93_RS22885 60849..61124 + 276 WP_123061045.1 Txe/YoeB family addiction module toxin Toxin
FOY93_RS22890 61237..61443 + 207 WP_123061046.1 hypothetical protein -
FOY93_RS22895 61440..61757 + 318 WP_123061047.1 hypothetical protein -
FOY93_RS22900 61831..62637 - 807 Protein_77 IS3 family transposase -
FOY93_RS22905 62709..63878 - 1170 Protein_78 IS256 family transposase -
FOY93_RS22910 64219..64479 - 261 WP_143345795.1 hypothetical protein -
FOY93_RS22915 64570..65024 - 455 Protein_80 transposase -
FOY93_RS22920 65614..66114 + 501 WP_123061084.1 Ail/Lom family outer membrane beta-barrel protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-10 / blaFRI-5 - 1..150509 150509


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10891.43 Da        Isoelectric Point: 10.4471

>T32815 WP_123061045.1 NZ_AP019635:60849-61124 [Enterobacter sp. 18A13]
MSKWNIKFTRNGADDLSYWRDTDKKKFERIRQLLRSIEADPLTGIGKPERLRHHKDPALYSRRIDQSHRLVYSIKSGEII
IYAARYHYGDK

Download         Length: 276 bp

>T32815 NZ_AP019635:60849-61124 [Enterobacter sp. 18A13]
TTGTCGAAGTGGAATATTAAGTTCACCAGGAACGGAGCTGATGACCTTAGCTACTGGCGTGATACTGACAAAAAGAAGTT
TGAGCGTATCCGGCAGCTGTTGCGCAGCATCGAGGCTGATCCGCTGACAGGTATCGGAAAACCCGAACGGCTGCGGCACC
ACAAAGATCCGGCGCTCTATTCCCGCCGGATTGATCAGAGTCACCGTCTGGTCTATTCAATCAAGAGCGGAGAAATCATC
ATCTACGCAGCCCGTTATCACTATGGTGACAAATAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9289.43 Da        Isoelectric Point: 4.5069

>AT32815 WP_103061436.1 NZ_AP019635:60623-60868 [Enterobacter sp. 18A13]
MHAINFTDARKHFADTMKRVTDDAEPVRVMRRDAPDIVMIDAGEYEALIETVYLFSNPANAAHINESMKQAERGEFVEVE
Y

Download         Length: 246 bp

>AT32815 NZ_AP019635:60623-60868 [Enterobacter sp. 18A13]
ATGCATGCAATCAATTTTACTGATGCCCGTAAACATTTTGCTGACACCATGAAGCGCGTCACTGATGATGCTGAACCTGT
ACGCGTCATGCGTCGTGACGCACCTGATATTGTTATGATCGATGCAGGAGAGTATGAGGCGCTAATCGAAACGGTCTATC
TGTTCAGCAATCCGGCGAACGCCGCGCATATCAATGAGTCAATGAAACAGGCGGAGCGCGGCGAATTTGTCGAAGTGGAA
TATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References