Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1624529..1625189 Replicon chromosome
Accession NZ_AP019632
Organism Enterobacter asburiae strain 1808-013

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FOY96_RS07675 Protein ID WP_126795992.1
Coordinates 1624529..1624882 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FOY96_RS07680 Protein ID WP_143346796.1
Coordinates 1624887..1625189 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY96_RS07655 1620671..1621588 + 918 WP_008499475.1 nitrogen assimilation transcriptional regulator NAC -
FOY96_RS07660 1621685..1622635 + 951 WP_023336219.1 HTH-type transcriptional regulator Cbl -
FOY96_RS07665 1622679..1623287 - 609 WP_143346794.1 glutathione S-transferase -
FOY96_RS07670 1623458..1624351 + 894 WP_143346795.1 LysR family transcriptional regulator -
FOY96_RS07675 1624529..1624882 + 354 WP_126795992.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOY96_RS07680 1624887..1625189 + 303 WP_143346796.1 XRE family transcriptional regulator Antitoxin
FOY96_RS07685 1625265..1626185 - 921 WP_143346797.1 LysR family transcriptional regulator -
FOY96_RS07690 1626327..1626716 + 390 WP_109845238.1 RidA family protein -
FOY96_RS07700 1627008..1627265 + 258 WP_033145928.1 antitoxin -
FOY96_RS07705 1627266..1627598 + 333 WP_032658722.1 type II toxin-antitoxin system PemK/MazF family toxin -
FOY96_RS07715 1627893..1630082 - 2190 WP_045142987.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13531.36 Da        Isoelectric Point: 9.0310

>T32788 WP_126795992.1 NZ_AP019632:1624529-1624882 [Enterobacter asburiae]
VWAINTTDRFDRWFTSLDDTERASVLAALLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREFTHWLNTLKERE

Download         Length: 354 bp

>T32788 NZ_AP019632:1624529-1624882 [Enterobacter asburiae]
GTGTGGGCAATTAACACGACGGACAGGTTTGATCGCTGGTTCACTTCGCTTGACGATACCGAACGCGCCAGCGTACTTGC
AGCACTGCTGGTTTTGCGAGAGAAGGGGCCGGGTTTATCGAGACCCTACGCTGATACGCTTAAAGGCTCTCGTCACAGCA
ACATGAAAGAGCTACGTATTCAGAGTAAGGGCGATCCCTTGCGGGCGTTTTTCGCCTTTGATCCAAACCGCACGGGTATC
GTGCTTTGTGCGGGCAATAAGGTCGGCAATGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGACCGGGAATTCAC
TCACTGGCTGAATACATTAAAAGAGAGGGAATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11064.86 Da        Isoelectric Point: 5.7316

>AT32788 WP_143346796.1 NZ_AP019632:1624887-1625189 [Enterobacter asburiae]
MGRTLEQLIADEKPEVVASAQAIATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGTHYEFVL

Download         Length: 303 bp

>AT32788 NZ_AP019632:1624887-1625189 [Enterobacter asburiae]
ATGGGAAGAACCCTTGAGCAGCTTATAGCGGATGAAAAGCCGGAGGTTGTCGCCAGCGCTCAGGCGATAGCAACGGATAT
TTTGCTCAACATTCATCTTGCTGAGTTACGCGAGAAAGTACAAAAAACGCAGGTAGAAATGGCGCAGGCGTTGGGTATCA
GGCAACCTACCGTTGCGGTAATGGAAAAGCCCGGGCGCGATTTGAAACTCTCTTCTCTCAAGCGCTACGTTGAGGCTGCG
GGCGGAAAGCTGCGGCTTGATGTGGAGCTGCCGGACGGCACGCACTATGAGTTTGTGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References