Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 983320..983977 Replicon chromosome
Accession NZ_AP019632
Organism Enterobacter asburiae strain 1808-013

Toxin (Protein)


Gene name higB Uniprot ID A0A808IF03
Locus tag FOY96_RS04705 Protein ID WP_033146338.1
Coordinates 983678..983977 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A808ICP3
Locus tag FOY96_RS04700 Protein ID WP_033146339.1
Coordinates 983320..983667 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY96_RS04670 978935..979822 + 888 WP_143346575.1 LysR family transcriptional regulator -
FOY96_RS04675 979843..981024 + 1182 WP_143346576.1 PLP-dependent aminotransferase family protein -
FOY96_RS04680 981109..981627 + 519 WP_143346577.1 hypothetical protein -
FOY96_RS04685 981630..982049 - 420 WP_033146342.1 nuclear transport factor 2 family protein -
FOY96_RS04690 982147..982878 + 732 WP_143346578.1 helix-turn-helix transcriptional regulator -
FOY96_RS04695 982850..983275 - 426 WP_033146340.1 nucleoside triphosphatase NudI -
FOY96_RS04700 983320..983667 - 348 WP_033146339.1 HigA family addiction module antidote protein Antitoxin
FOY96_RS04705 983678..983977 - 300 WP_033146338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOY96_RS04710 984229..985398 - 1170 WP_086374946.1 HlyD family efflux transporter periplasmic adaptor subunit -
FOY96_RS04715 985409..987607 - 2199 WP_143346579.1 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11691.32 Da        Isoelectric Point: 10.0346

>T32787 WP_033146338.1 NZ_AP019632:c983977-983678 [Enterobacter asburiae]
MISYFRDQWLEDFFLYGRSSNVIPANLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK

Download         Length: 300 bp

>T32787 NZ_AP019632:c983977-983678 [Enterobacter asburiae]
ATGATTAGTTATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTTTACGGCAGATCGAGCAATGTTATTCCTGCAAATCT
GGAAACAGCGCTTGCGAGAAAGCTCGATATCATCAGGGCAGCAACCTCGCACAGGGATTTGCGATCGCCACCGGGCAATA
TGTATGAAGCATTGAATCCTCCGCTGAAGGGATATTCCTCAATCCGGGTAAACAGGCAATACAGGCTCGTATTTCGCTGG
ACAGAGGGTAAAGCAGAAGATCTCTACCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13066.02 Da        Isoelectric Point: 7.0134

>AT32787 WP_033146339.1 NZ_AP019632:c983667-983320 [Enterobacter asburiae]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNPRTQEELSRIKTVADVMAKRKSGQPDVA

Download         Length: 348 bp

>AT32787 NZ_AP019632:c983667-983320 [Enterobacter asburiae]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGACGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAGCGATCTGGCGGAGATGCTCAATGTTCACCGCAACACCATCAGCGCGCTGGTCAATAATAATCGCAAGCTGA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTGATACCACGATTGAATTTTGGCTTAACTTACAGCTGAACGTCGAT
ATCTGGGAAGCGCAATCCAATCCCAGGACGCAGGAGGAGCTAAGCCGTATAAAGACCGTTGCGGACGTCATGGCTAAGCG
AAAATCTGGCCAGCCGGATGTAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808IF03

Antitoxin

Source ID Structure
AlphaFold DB A0A808ICP3

References