Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3623685..3624342 Replicon chromosome
Accession NZ_AP019630
Organism Enterobacter asburiae strain 17Nkhm-UP2

Toxin (Protein)


Gene name higB Uniprot ID A0A808IF03
Locus tag FOY94_RS17370 Protein ID WP_033146338.1
Coordinates 3623685..3623984 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A808ICP3
Locus tag FOY94_RS17375 Protein ID WP_033146339.1
Coordinates 3623995..3624342 (+) Length 116 a.a.

Genomic Context


FOY94_RS17360FOY94_RS17365FOY94_RS17370FOY94_RS17375FOY94_RS17380FOY94_RS17400FOY94_RS17385FOY94_RS17390FOY94_RS17395FOY94_RS17405
Location: 3620055..3622253 (2199 bp)
Type: Others
Protein ID: WP_048979782.1
Location: 3622264..3623433 (1170 bp)
Type: Others
Protein ID: WP_086374946.1
Location: 3623685..3623984 (300 bp)
Type: Toxin
Protein ID: WP_033146338.1
Location: 3623995..3624342 (348 bp)
Type: Antitoxin
Protein ID: WP_033146339.1
Location: 3624387..3624812 (426 bp)
Type: Others
Protein ID: WP_048979783.1
Location: 3627596..3628198 (603 bp)
Type: Others
Protein ID: WP_048979787.1
Location: 3624815..3625324 (510 bp)
Type: Others
Protein ID: WP_048979784.1
Location: 3625409..3626590 (1182 bp)
Type: Others
Protein ID: WP_048979785.1
Location: 3626611..3627498 (888 bp)
Type: Others
Protein ID: WP_048979786.1
Location: 3628192..3628926 (735 bp)
Type: Others
Protein ID: WP_048979788.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FOY94_RS173603620055..3622253+2199WP_048979782.1type I secretion system permease/ATPase-
FOY94_RS173653622264..3623433+1170WP_086374946.1HlyD family efflux transporter periplasmic adaptor subunit-
FOY94_RS173703623685..3623984+300WP_033146338.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FOY94_RS173753623995..3624342+348WP_033146339.1HigA family addiction module antidote proteinAntitoxin
FOY94_RS173803624387..3624812+426WP_048979783.1nucleoside triphosphatase NudI-
FOY94_RS173853624815..3625324-510WP_048979784.1hypothetical protein-
FOY94_RS173903625409..3626590-1182WP_048979785.1PLP-dependent aminotransferase family protein-
FOY94_RS173953626611..3627498-888WP_048979786.1LysR family transcriptional regulator-
FOY94_RS174003627596..3628198+603WP_048979787.1short chain dehydrogenase-
FOY94_RS174053628192..3628926-735WP_048979788.1class I SAM-dependent methyltransferase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-95)

Antitoxin

(8-86)


Sequences


Toxin        


Download         Length: 100 a.a.        Molecular weight: 11691.32 Da        Isoelectric Point: 10.0346

>T32782 WP_033146338.1 NZ_AP019630:3623685-3623984 [Enterobacter asburiae]
MISYFRDQWLEDFFLYGRSSNVIPANLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK

Download         Length: 300 bp

>T32782 NZ_AP019630:3623685-3623984 [Enterobacter asburiae]
ATGATTAGTTATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTTTACGGCAGATCGAGCAATGTTATTCCTGCAAATCT
GGAAACAGCGCTTGCGAGAAAGCTCGATATCATCAGGGCAGCAACCTCGCACAGGGATTTGCGATCGCCACCGGGCAATA
TGTATGAAGCATTGAATCCTCCGCTGAAGGGATATTCCTCAATCCGGGTAAACAGGCAATACAGGCTCGTATTTCGCTGG
ACAGAGGGTAAAGCAGAAGATCTCTACCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13066.02 Da        Isoelectric Point: 7.0134

>AT32782 WP_033146339.1 NZ_AP019630:3623995-3624342 [Enterobacter asburiae]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNPRTQEELSRIKTVADVMAKRKSGQPDVA

Download         Length: 348 bp

>AT32782 NZ_AP019630:3623995-3624342 [Enterobacter asburiae]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGACGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAGCGATCTGGCGGAGATGCTCAATGTTCACCGCAACACCATCAGCGCGCTGGTCAATAACAATCGCAAGCTGA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTGATACCACGATTGAATTTTGGCTTAACTTACAGCTGAACGTCGAT
ATCTGGGAAGCGCAATCCAACCCCAGGACGCAGGAGGAGCTAAGCCGTATAAAGACCGTTGCGGACGTCATGGCTAAGCG
AAAATCTGGCCAGCCGGATGTAGCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A808IF03


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A808ICP3

References