Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3623685..3624342 Replicon chromosome
Accession NZ_AP019630
Organism Enterobacter asburiae strain 17Nkhm-UP2

Toxin (Protein)


Gene name higB Uniprot ID A0A808IF03
Locus tag FOY94_RS17370 Protein ID WP_033146338.1
Coordinates 3623685..3623984 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A808ICP3
Locus tag FOY94_RS17375 Protein ID WP_033146339.1
Coordinates 3623995..3624342 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY94_RS17360 3620055..3622253 + 2199 WP_048979782.1 type I secretion system permease/ATPase -
FOY94_RS17365 3622264..3623433 + 1170 WP_086374946.1 HlyD family efflux transporter periplasmic adaptor subunit -
FOY94_RS17370 3623685..3623984 + 300 WP_033146338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOY94_RS17375 3623995..3624342 + 348 WP_033146339.1 HigA family addiction module antidote protein Antitoxin
FOY94_RS17380 3624387..3624812 + 426 WP_048979783.1 nucleoside triphosphatase NudI -
FOY94_RS17385 3624815..3625324 - 510 WP_048979784.1 hypothetical protein -
FOY94_RS17390 3625409..3626590 - 1182 WP_048979785.1 PLP-dependent aminotransferase family protein -
FOY94_RS17395 3626611..3627498 - 888 WP_048979786.1 LysR family transcriptional regulator -
FOY94_RS17400 3627596..3628198 + 603 WP_048979787.1 short chain dehydrogenase -
FOY94_RS17405 3628192..3628926 - 735 WP_048979788.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11691.32 Da        Isoelectric Point: 10.0346

>T32782 WP_033146338.1 NZ_AP019630:3623685-3623984 [Enterobacter asburiae]
MISYFRDQWLEDFFLYGRSSNVIPANLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK

Download         Length: 300 bp

>T32782 NZ_AP019630:3623685-3623984 [Enterobacter asburiae]
ATGATTAGTTATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTTTACGGCAGATCGAGCAATGTTATTCCTGCAAATCT
GGAAACAGCGCTTGCGAGAAAGCTCGATATCATCAGGGCAGCAACCTCGCACAGGGATTTGCGATCGCCACCGGGCAATA
TGTATGAAGCATTGAATCCTCCGCTGAAGGGATATTCCTCAATCCGGGTAAACAGGCAATACAGGCTCGTATTTCGCTGG
ACAGAGGGTAAAGCAGAAGATCTCTACCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13066.02 Da        Isoelectric Point: 7.0134

>AT32782 WP_033146339.1 NZ_AP019630:3623995-3624342 [Enterobacter asburiae]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNPRTQEELSRIKTVADVMAKRKSGQPDVA

Download         Length: 348 bp

>AT32782 NZ_AP019630:3623995-3624342 [Enterobacter asburiae]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGACGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAGCGATCTGGCGGAGATGCTCAATGTTCACCGCAACACCATCAGCGCGCTGGTCAATAACAATCGCAAGCTGA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTGATACCACGATTGAATTTTGGCTTAACTTACAGCTGAACGTCGAT
ATCTGGGAAGCGCAATCCAACCCCAGGACGCAGGAGGAGCTAAGCCGTATAAAGACCGTTGCGGACGTCATGGCTAAGCG
AAAATCTGGCCAGCCGGATGTAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808IF03

Antitoxin

Source ID Structure
AlphaFold DB A0A808ICP3

References