Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2963280..2963940 Replicon chromosome
Accession NZ_AP019630
Organism Enterobacter asburiae strain 17Nkhm-UP2

Toxin (Protein)


Gene name higB Uniprot ID A0A808IFD9
Locus tag FOY94_RS14335 Protein ID WP_048980127.1
Coordinates 2963587..2963940 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1Z3MX79
Locus tag FOY94_RS14330 Protein ID WP_029741460.1
Coordinates 2963280..2963582 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY94_RS14310 2959257..2961446 + 2190 WP_045356712.1 TonB-dependent siderophore receptor -
FOY94_RS14320 2961741..2962142 - 402 WP_048980122.1 RidA family protein -
FOY94_RS14325 2962284..2963204 + 921 WP_048980124.1 LysR family transcriptional regulator -
FOY94_RS14330 2963280..2963582 - 303 WP_029741460.1 XRE family transcriptional regulator Antitoxin
FOY94_RS14335 2963587..2963940 - 354 WP_048980127.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOY94_RS14340 2964118..2965011 - 894 WP_048980130.1 LysR family transcriptional regulator -
FOY94_RS14345 2965182..2965790 + 609 WP_080973612.1 glutathione S-transferase family protein -
FOY94_RS14350 2965834..2966784 - 951 WP_023336219.1 HTH-type transcriptional regulator Cbl -
FOY94_RS14355 2966881..2967798 - 918 WP_033145933.1 nitrogen assimilation transcriptional regulator NAC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13599.44 Da        Isoelectric Point: 8.9620

>T32780 WP_048980127.1 NZ_AP019630:c2963940-2963587 [Enterobacter asburiae]
VWAINTTDRFDRWFTSLDDTDRASVLAALLVLREKGPGLSRPYADTLKGSRYSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREFTHWLDRLKERE

Download         Length: 354 bp

>T32780 NZ_AP019630:c2963940-2963587 [Enterobacter asburiae]
GTGTGGGCAATTAACACGACGGACAGGTTTGATCGCTGGTTCACTTCGCTTGACGATACCGATCGCGCCAGCGTACTTGC
AGCACTGCTTGTTTTGCGAGAGAAGGGGCCGGGTTTATCGAGACCCTACGCTGATACGCTTAAAGGCTCTCGTTACAGCA
ACATGAAAGAGCTACGTATTCAGAGTAAGGGCGATCCCTTGCGGGCGTTTTTCGCCTTTGATCCAAACCGCACGGGTATC
GTGCTTTGTGCGGGCAATAAGGTCGGCAATGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGACCGGGAATTCAC
TCACTGGCTGGATAGATTAAAAGAGAGGGAATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11050.83 Da        Isoelectric Point: 5.7316

>AT32780 WP_029741460.1 NZ_AP019630:c2963582-2963280 [Enterobacter asburiae]
MGRTLEQLIADEKPEVVASAQAIATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT32780 NZ_AP019630:c2963582-2963280 [Enterobacter asburiae]
ATGGGAAGAACCCTTGAGCAGCTTATAGCGGATGAAAAGCCGGAGGTTGTCGCCAGCGCTCAGGCGATAGCAACGGATAT
TTTGCTCAACATTCATCTTGCTGAGTTACGCGAGAAAGTACAAAAAACGCAGGTAGAAATGGCGCAGGCGTTGGGTATCA
GGCAACCTACCGTTGCGGTAATGGAAAAGCCCGGGCGCGATTTGAAACTCTCTTCTCTCAAGCGCTACGTTGAGGCTGCG
GGCGGAAAGCTGCGGCTTGATGTGGAGCTGCCGGATGGCTCGCACTATGAGTTTGTGCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808IFD9

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MX79

References