Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 4395302..4395837 | Replicon | chromosome |
Accession | NZ_AP019620 | ||
Organism | Streptomyces antimycoticus strain NBRC 100767 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | - |
Locus tag | GYK45_RS18130 | Protein ID | WP_137967268.1 |
Coordinates | 4395302..4395556 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | - |
Locus tag | GYK45_RS18135 | Protein ID | WP_161560135.1 |
Coordinates | 4395553..4395837 (-) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GYK45_RS18115 | 4391809..4392561 | - | 753 | WP_161560133.1 | GntR family transcriptional regulator | - |
GYK45_RS18120 | 4392915..4394380 | + | 1466 | Protein_3643 | M1 family metallopeptidase | - |
GYK45_RS18125 | 4394433..4395014 | + | 582 | WP_161560134.1 | Uma2 family endonuclease | - |
GYK45_RS18130 | 4395302..4395556 | - | 255 | WP_137967268.1 | Txe/YoeB family addiction module toxin | Toxin |
GYK45_RS18135 | 4395553..4395837 | - | 285 | WP_161560135.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
GYK45_RS18140 | 4395930..4396835 | - | 906 | WP_137967266.1 | LysR family transcriptional regulator | - |
GYK45_RS18145 | 4396906..4397223 | + | 318 | WP_161560136.1 | hypothetical protein | - |
GYK45_RS18150 | 4397220..4397972 | + | 753 | WP_161560137.1 | SDR family oxidoreductase | - |
GYK45_RS18155 | 4398151..4399503 | + | 1353 | WP_161560138.1 | aromatic acid/H+ symport family MFS transporter | - |
GYK45_RS18160 | 4399500..4400009 | + | 510 | WP_161560139.1 | amidohydrolase family protein | - |
GYK45_RS18165 | 4399925..4400158 | + | 234 | WP_161560140.1 | amidohydrolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10096.60 Da Isoelectric Point: 8.4461
>T32767 WP_137967268.1 NZ_AP019620:c4395556-4395302 [Streptomyces antimycoticus]
VRLVFEDQGWEDYTSWLKNDRKMLARINRLIEDVKRDPFAGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDKEIVILAA
RYHY
VRLVFEDQGWEDYTSWLKNDRKMLARINRLIEDVKRDPFAGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDKEIVILAA
RYHY
Download Length: 255 bp
>T32767 NZ_AP019620:c4395556-4395302 [Streptomyces antimycoticus]
GTGAGGCTTGTCTTCGAGGATCAGGGCTGGGAGGACTACACGTCCTGGCTCAAGAACGATCGCAAGATGCTGGCTCGGAT
CAACAGGCTCATTGAGGACGTCAAGCGCGACCCCTTCGCGGGGATCGGCAAGCCCGAGCCGCTCAAGTACCACTTGCCCG
GGGCGTGGTCGAGGCGGATCGACGACGAGCACCGCTTGGTCTACCTGGTCACGGACAAGGAGATCGTGATCCTCGCGGCT
CGCTACCACTACTGA
GTGAGGCTTGTCTTCGAGGATCAGGGCTGGGAGGACTACACGTCCTGGCTCAAGAACGATCGCAAGATGCTGGCTCGGAT
CAACAGGCTCATTGAGGACGTCAAGCGCGACCCCTTCGCGGGGATCGGCAAGCCCGAGCCGCTCAAGTACCACTTGCCCG
GGGCGTGGTCGAGGCGGATCGACGACGAGCACCGCTTGGTCTACCTGGTCACGGACAAGGAGATCGTGATCCTCGCGGCT
CGCTACCACTACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10148.35 Da Isoelectric Point: 4.6652
>AT32767 WP_161560135.1 NZ_AP019620:c4395837-4395553 [Streptomyces antimycoticus]
MSITASEARKALFPLIKKVNDDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALGNINVSEREL
IDPDSPDAAGEDAA
MSITASEARKALFPLIKKVNDDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALGNINVSEREL
IDPDSPDAAGEDAA
Download Length: 285 bp
>AT32767 NZ_AP019620:c4395837-4395553 [Streptomyces antimycoticus]
ATGTCGATAACTGCGAGCGAAGCCCGCAAGGCTCTCTTTCCGCTGATCAAGAAGGTCAACGACGATCACGAGGCAATCGA
GATCGTCTCCAAGCATGGCAACGCCGTGCTTGTCTCGGCCGAGGACTACGCGGCGCTGCGCGAGGGCTCGTACCTGTTGC
GCTCGCCCGCGAACGCACGCCGACTGCTCAAGGCGTACGAGAACGCGCTGGGCAACATCAACGTGTCGGAGCGGGAGCTG
ATCGACCCCGACTCGCCGGATGCGGCCGGCGAGGATGCTGCGTGA
ATGTCGATAACTGCGAGCGAAGCCCGCAAGGCTCTCTTTCCGCTGATCAAGAAGGTCAACGACGATCACGAGGCAATCGA
GATCGTCTCCAAGCATGGCAACGCCGTGCTTGTCTCGGCCGAGGACTACGCGGCGCTGCGCGAGGGCTCGTACCTGTTGC
GCTCGCCCGCGAACGCACGCCGACTGCTCAAGGCGTACGAGAACGCGCTGGGCAACATCAACGTGTCGGAGCGGGAGCTG
ATCGACCCCGACTCGCCGGATGCGGCCGGCGAGGATGCTGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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