Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4395302..4395837 Replicon chromosome
Accession NZ_AP019620
Organism Streptomyces antimycoticus strain NBRC 100767

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GYK45_RS18130 Protein ID WP_137967268.1
Coordinates 4395302..4395556 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GYK45_RS18135 Protein ID WP_161560135.1
Coordinates 4395553..4395837 (-) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYK45_RS18115 4391809..4392561 - 753 WP_161560133.1 GntR family transcriptional regulator -
GYK45_RS18120 4392915..4394380 + 1466 Protein_3643 M1 family metallopeptidase -
GYK45_RS18125 4394433..4395014 + 582 WP_161560134.1 Uma2 family endonuclease -
GYK45_RS18130 4395302..4395556 - 255 WP_137967268.1 Txe/YoeB family addiction module toxin Toxin
GYK45_RS18135 4395553..4395837 - 285 WP_161560135.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GYK45_RS18140 4395930..4396835 - 906 WP_137967266.1 LysR family transcriptional regulator -
GYK45_RS18145 4396906..4397223 + 318 WP_161560136.1 hypothetical protein -
GYK45_RS18150 4397220..4397972 + 753 WP_161560137.1 SDR family oxidoreductase -
GYK45_RS18155 4398151..4399503 + 1353 WP_161560138.1 aromatic acid/H+ symport family MFS transporter -
GYK45_RS18160 4399500..4400009 + 510 WP_161560139.1 amidohydrolase family protein -
GYK45_RS18165 4399925..4400158 + 234 WP_161560140.1 amidohydrolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-84)

Antitoxin

(2-64)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10096.60 Da        Isoelectric Point: 8.4461

>T32767 WP_137967268.1 NZ_AP019620:c4395556-4395302 [Streptomyces antimycoticus]
VRLVFEDQGWEDYTSWLKNDRKMLARINRLIEDVKRDPFAGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDKEIVILAA
RYHY

Download         Length: 255 bp

>T32767 NZ_AP019620:c4395556-4395302 [Streptomyces antimycoticus]
GTGAGGCTTGTCTTCGAGGATCAGGGCTGGGAGGACTACACGTCCTGGCTCAAGAACGATCGCAAGATGCTGGCTCGGAT
CAACAGGCTCATTGAGGACGTCAAGCGCGACCCCTTCGCGGGGATCGGCAAGCCCGAGCCGCTCAAGTACCACTTGCCCG
GGGCGTGGTCGAGGCGGATCGACGACGAGCACCGCTTGGTCTACCTGGTCACGGACAAGGAGATCGTGATCCTCGCGGCT
CGCTACCACTACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10148.35 Da        Isoelectric Point: 4.6652

>AT32767 WP_161560135.1 NZ_AP019620:c4395837-4395553 [Streptomyces antimycoticus]
MSITASEARKALFPLIKKVNDDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALGNINVSEREL
IDPDSPDAAGEDAA

Download         Length: 285 bp

>AT32767 NZ_AP019620:c4395837-4395553 [Streptomyces antimycoticus]
ATGTCGATAACTGCGAGCGAAGCCCGCAAGGCTCTCTTTCCGCTGATCAAGAAGGTCAACGACGATCACGAGGCAATCGA
GATCGTCTCCAAGCATGGCAACGCCGTGCTTGTCTCGGCCGAGGACTACGCGGCGCTGCGCGAGGGCTCGTACCTGTTGC
GCTCGCCCGCGAACGCACGCCGACTGCTCAAGGCGTACGAGAACGCGCTGGGCAACATCAACGTGTCGGAGCGGGAGCTG
ATCGACCCCGACTCGCCGGATGCGGCCGGCGAGGATGCTGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References