Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1588948..1589537 Replicon chromosome
Accession NZ_AP019547
Organism Candidatus Nitrotoga sp. AM1P

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag W01_RS07040 Protein ID WP_173053317.1
Coordinates 1589262..1589537 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag W01_RS07035 Protein ID WP_173053315.1
Coordinates 1588948..1589253 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
W01_RS07005 1584021..1585604 - 1584 WP_173053305.1 phage tail sheath family protein -
W01_RS07010 1585649..1586014 - 366 WP_173053307.1 hypothetical protein -
W01_RS07015 1586495..1586773 - 279 WP_173053309.1 DUF2442 domain-containing protein -
W01_RS07020 1586751..1586984 - 234 WP_173053311.1 DUF4160 domain-containing protein -
W01_RS07025 1587211..1587882 - 672 WP_173053313.1 hypothetical protein -
W01_RS13915 1587983..1588978 - 996 WP_198421259.1 hypothetical protein -
W01_RS07035 1588948..1589253 - 306 WP_173053315.1 HigA family addiction module antidote protein Antitoxin
W01_RS07040 1589262..1589537 - 276 WP_173053317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
W01_RS07045 1589915..1591096 - 1182 WP_173053319.1 alanine--glyoxylate aminotransferase family protein -
W01_RS07050 1591140..1592390 - 1251 WP_173053321.1 glycolate oxidase subunit GlcF -
W01_RS07055 1592396..1593460 - 1065 WP_173053323.1 glycolate oxidase subunit GlcE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-91)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10464.03 Da        Isoelectric Point: 8.0834

>T32762 WP_173053317.1 NZ_AP019547:c1589537-1589262 [Candidatus Nitrotoga sp. AM1P]
MIESFMHKGLEELFEKGKSAKVQQALVGRALRRLDAINTAKTPDVLNLPGFDFHLLQGKPKRYSVHVNGPWCITFEWEGE
NALRINLENYH

Download         Length: 276 bp

>T32762 NZ_AP019547:c1589537-1589262 [Candidatus Nitrotoga sp. AM1P]
ATGATTGAATCGTTCATGCACAAGGGGCTGGAAGAGCTTTTTGAAAAAGGTAAGAGCGCCAAGGTGCAGCAAGCCTTGGT
GGGGCGCGCATTGCGGCGACTGGATGCCATCAACACTGCCAAAACACCGGATGTGTTGAATCTTCCGGGCTTCGATTTCC
ATCTCTTGCAAGGCAAGCCCAAGCGATACAGCGTGCATGTAAATGGGCCGTGGTGTATTACATTCGAATGGGAAGGCGAG
AATGCGCTACGGATCAATTTGGAAAATTATCACTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11120.84 Da        Isoelectric Point: 6.7147

>AT32762 WP_173053315.1 NZ_AP019547:c1589253-1588948 [Candidatus Nitrotoga sp. AM1P]
MRTRKPTHPGAILREDVLPDLGMSVSAFARNLGVSRQTLHAVLAERSGISPEMALRLGALLGNGAQLWVDMQSKYDLWQA
EDKLHDVLLSIQCLTDNQVLA

Download         Length: 306 bp

>AT32762 NZ_AP019547:c1589253-1588948 [Candidatus Nitrotoga sp. AM1P]
ATGCGGACACGTAAACCAACTCACCCCGGCGCAATCTTGCGCGAAGACGTTCTGCCGGATTTGGGAATGTCTGTGAGCGC
TTTTGCTCGCAATCTTGGAGTCTCGCGCCAAACTCTGCATGCGGTACTGGCCGAGCGTAGCGGCATCTCCCCGGAAATGG
CGCTACGTTTGGGTGCATTGCTAGGTAATGGCGCTCAGTTGTGGGTGGATATGCAATCGAAATACGATCTATGGCAGGCT
GAGGATAAACTTCATGACGTGCTGTTGAGTATCCAATGCCTCACCGACAACCAGGTATTGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References