32761

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1292721..1293314 Replicon chromosome
Accession NZ_AP019547
Organism Candidatus Nitrotoga sp. AM1P

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag W01_RS05725 Protein ID WP_173052857.1
Coordinates 1293036..1293314 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag W01_RS05720 Protein ID WP_173052855.1
Coordinates 1292721..1293023 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
W01_RS05695 1288754..1289911 + 1158 Protein_1113 IS4 family transposase -
W01_RS05700 1290101..1290914 + 814 Protein_1114 HDOD domain-containing protein -
W01_RS05705 1291201..1291608 - 408 WP_173052854.1 RNA-binding S4 domain-containing protein -
W01_RS05715 1292375..1292587 - 213 Protein_1116 IS1595 family transposase -
W01_RS05720 1292721..1293023 - 303 WP_173052855.1 HigA family addiction module antidote protein Antitoxin
W01_RS05725 1293036..1293314 - 279 WP_173052857.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
W01_RS05730 1293338..1294602 - 1265 Protein_1119 integrase family protein -
W01_RS05735 1295144..1295425 + 282 WP_173052859.1 Tar ligand binding domain-containing protein -
W01_RS05740 1295377..1296255 + 879 WP_173052860.1 response regulator -
W01_RS05745 1296469..1298148 + 1680 WP_173052863.1 diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-68)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10859.35 Da        Isoelectric Point: 7.8507

>T32761 WP_173052857.1 NZ_AP019547:c1293314-1293036 [Candidatus Nitrotoga sp. AM1P]
MIKSFRCKNTEALYQGKRVRKFEAFAMQAENRLEILDNAKTIHDLMGLPGNRFESLVGDRAGQYSIRVNQQWRLCFEWKD
ADAYNVEIVDYH

Download         Length: 279 bp

>T32761 NZ_AP019547:c1293314-1293036 [Candidatus Nitrotoga sp. AM1P]
ATGATTAAATCCTTTCGCTGCAAGAATACGGAAGCCCTCTACCAAGGCAAGCGCGTAAGGAAATTTGAAGCCTTCGCAAT
GCAGGCAGAAAACAGACTCGAGATTTTGGACAATGCCAAAACCATTCATGATTTGATGGGATTGCCTGGCAACCGCTTTG
AATCATTAGTCGGAGACCGAGCTGGACAGTACAGCATACGCGTCAATCAACAATGGCGCTTATGCTTCGAGTGGAAAGAT
GCGGACGCTTATAATGTGGAAATCGTTGATTACCATTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11090.86 Da        Isoelectric Point: 8.6009

>AT32761 WP_173052855.1 NZ_AP019547:c1293023-1292721 [Candidatus Nitrotoga sp. AM1P]
MSNKMRAIHPGEILKDELFELNLSANAFAKALDVPTNRVTTILNEQRSVTADTALRLARFFGTTPDFWMSLQASYDVKKA
IAAAGKEIEKNVIPKELLIA

Download         Length: 303 bp

>AT32761 NZ_AP019547:c1293023-1292721 [Candidatus Nitrotoga sp. AM1P]
ATGAGTAACAAAATGCGGGCGATTCACCCCGGCGAAATCCTTAAAGATGAATTATTCGAACTCAATCTTTCGGCTAATGC
CTTCGCCAAGGCGCTGGATGTACCCACAAACCGGGTTACTACAATTTTAAATGAACAGCGAAGCGTTACTGCAGATACTG
CTCTTCGTTTGGCCAGATTTTTTGGAACGACGCCGGATTTTTGGATGAGTCTACAAGCTAGCTACGATGTCAAAAAAGCG
ATTGCAGCTGCTGGCAAGGAAATTGAGAAGAACGTTATACCAAAAGAACTTTTGATTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References