Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 178712..179331 Replicon chromosome
Accession NZ_AP019547
Organism Candidatus Nitrotoga sp. AM1P

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag W01_RS00835 Protein ID WP_173051775.1
Coordinates 179053..179331 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag W01_RS00830 Protein ID WP_173051774.1
Coordinates 178712..179041 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
W01_RS00805 174732..174920 - 189 WP_173051636.1 hypothetical protein -
W01_RS00810 174929..175195 - 267 WP_173051771.1 type II toxin-antitoxin system RelE/ParE family toxin -
W01_RS00815 175179..175406 - 228 WP_173051772.1 CopG family transcriptional regulator -
W01_RS00820 175494..178280 - 2787 WP_173051773.1 class I SAM-dependent DNA methyltransferase -
W01_RS13800 178414..178593 + 180 WP_198421311.1 hypothetical protein -
W01_RS00830 178712..179041 - 330 WP_173051774.1 HigA family addiction module antidote protein Antitoxin
W01_RS00835 179053..179331 - 279 WP_173051775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
W01_RS13805 179608..179784 - 177 WP_198421312.1 hypothetical protein -
W01_RS00845 179854..181452 - 1599 WP_173051776.1 ABC-F family ATPase -
W01_RS00850 181573..182844 + 1272 WP_173051777.1 glutamate--cysteine ligase -
W01_RS00855 182893..183318 + 426 WP_173051778.1 PTS sugar transporter subunit IIA -
W01_RS00860 183290..183559 + 270 WP_173051779.1 HPr family phosphocarrier protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-68)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 11081.74 Da        Isoelectric Point: 10.0348

>T32759 WP_173051775.1 NZ_AP019547:c179331-179053 [Candidatus Nitrotoga sp. AM1P]
MIKSFKCADTEKLFHDILVARFRSIERPSRRKLLYLHRARTLDDLKQPPGNRLEALKGNRKGQYSIRINDQWRICFKWSD
SDVYDVEIVDYH

Download         Length: 279 bp

>T32759 NZ_AP019547:c179331-179053 [Candidatus Nitrotoga sp. AM1P]
ATGATTAAGTCGTTCAAATGCGCTGACACCGAAAAACTGTTCCACGATATTCTGGTTGCGCGATTTCGTTCGATTGAACG
CCCTAGCCGTCGCAAGTTGCTTTATTTGCATCGCGCACGAACGCTCGACGACTTGAAGCAACCACCCGGCAATCGTCTGG
AAGCACTTAAAGGAAATCGCAAAGGGCAATACAGCATCCGCATCAATGACCAGTGGCGCATCTGCTTTAAGTGGTCAGAC
AGCGATGTTTATGATGTGGAAATCGTGGACTATCACTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12222.26 Da        Isoelectric Point: 7.0117

>AT32759 WP_173051774.1 NZ_AP019547:c179041-178712 [Candidatus Nitrotoga sp. AM1P]
MTQKLLDPIPPGEILLEEFMKPMGVSINALSRDVSVPPNRISEIVNGKRSITADTALRLGKYFGVSPEIWLDLQSDYDIR
LAQRTVWPQIEPLVRAHTAKMLAQVPISQ

Download         Length: 330 bp

>AT32759 NZ_AP019547:c179041-178712 [Candidatus Nitrotoga sp. AM1P]
ATGACTCAAAAATTACTCGATCCTATTCCGCCCGGCGAGATTTTGTTGGAAGAATTCATGAAGCCCATGGGCGTCAGCAT
CAATGCGTTATCAAGAGATGTAAGTGTACCGCCCAATCGCATCAGTGAAATTGTGAATGGCAAGCGCTCGATCACTGCCG
ATACTGCATTGCGCCTTGGCAAGTATTTCGGCGTATCCCCGGAAATCTGGCTCGATCTACAAAGCGATTACGACATCCGC
TTGGCACAGCGCACCGTCTGGCCGCAGATTGAGCCGCTTGTCCGCGCCCATACAGCAAAAATGTTGGCGCAGGTGCCAAT
CAGCCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References