Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2572128..2572645 Replicon chromosome
Accession NZ_AP019545
Organism Staphylococcus aureus strain KG-22

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag GDK20_RS13190 Protein ID WP_000113265.1
Coordinates 2572128..2572394 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag GDK20_RS13195 Protein ID WP_000584499.1
Coordinates 2572394..2572645 (-) Length 84 a.a.

Genomic Context

GDK20_RS13215GDK20_RS13160GDK20_RS13165GDK20_RS13170GDK20_RS13175GDK20_RS13180GDK20_RS13185GDK20_RS13190GDK20_RS13195GDK20_RS13200GDK20_RS13205GDK20_RS13210GDK20_RS13220GDK20_RS13225
Location: 2574153..2575403 (1251 bp)
Type: Others
Protein ID: WP_001012225.1
Location: 2567556..2568092 (537 bp)
Type: Others
Protein ID: WP_000169317.1
Location: 2568326..2569150 (825 bp)
Type: Others
Protein ID: WP_000572038.1
Location: 2569367..2569549 (183 bp)
Type: Others
Protein ID: WP_000230292.1
Location: 2569633..2570100 (468 bp)
Type: Others
Protein ID: WP_000153347.1
Location: 2570286..2571833 (1548 bp)
Type: Others
Protein ID: WP_000727772.1
Location: 2572022..2572093 (72 bp)
Type: Others
Protein ID: Protein_2484
Location: 2572128..2572394 (267 bp)
Type: Toxin
Protein ID: WP_000113265.1
Location: 2572394..2572645 (252 bp)
Type: Antitoxin
Protein ID: WP_000584499.1
Location: 2572810..2572911 (102 bp)
Type: Others
Protein ID: Protein_2487
Location: 2572918..2573517 (600 bp)
Type: Others
Protein ID: WP_000162810.1
Location: 2573536..2573898 (363 bp)
Type: Others
Protein ID: WP_000819843.1
Location: 2575500..2576231 (732 bp)
Type: Others
Protein ID: WP_000615461.1
Location: 2576228..2576947 (720 bp)
Type: Others
Protein ID: WP_000479576.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GDK20_RS131602567556..2568092-537WP_000169317.1GNAT family N-acetyltransferase-
GDK20_RS131652568326..2569150-825WP_000572038.1formate/nitrite transporter family protein-
GDK20_RS131702569367..2569549-183WP_000230292.1hypothetical protein-
GDK20_RS131752569633..2570100-468WP_000153347.1SRPBCC domain-containing protein-
GDK20_RS131802570286..2571833-1548WP_000727772.1zinc ABC transporter substrate-binding lipoprotein AdcA-
GDK20_RS131852572022..2572093-72Protein_2484hypothetical protein-
GDK20_RS131902572128..2572394-267WP_000113265.1Txe/YoeB family addiction module toxinToxin
GDK20_RS131952572394..2572645-252WP_000584499.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GDK20_RS132002572810..2572911-102Protein_2487hypothetical protein-
GDK20_RS132052572918..2573517-600WP_000162810.1DsbA family protein-
GDK20_RS132102573536..2573898-363WP_000819843.1DUF4467 domain-containing protein-
GDK20_RS132152574153..2575403+1251WP_001012225.1FemA/FemB family glycyltransferase FmhA-
GDK20_RS132202575500..2576231-732WP_000615461.1amino acid ABC transporter ATP-binding protein-
GDK20_RS132252576228..2576947-720WP_000479576.1amino acid ABC transporter permease-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T32753 WP_000113265.1 NZ_AP019545:c2572394-2572128 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T32753 NZ_AP019545:c2572394-2572128 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT32753 WP_000584499.1 NZ_AP019545:c2572645-2572394 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT32753 NZ_AP019545:c2572645-2572394 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB7BWF

Antitoxin

Loading, please wait
Source
ID
Structure
PDB6L8G
PDB6L8F
PDB7BWF
PDB6L8E
AlphaFold DBT1YB60

References