Detailed information of TA system TA032740

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1936246..1936426
• Replicon: chromosome
• Accession: NZ_AP019545
• Organism: Staphylococcus aureus strain KG-22

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: GDK20_RS09490
• Protein ID: WP_001801861.1
• Coordinates: 1936246..1936341 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1936369..1936426 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GDK20_RS09460	1931409..1932059	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
GDK20_RS09465	1932140..1933135	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
GDK20_RS09470	1933210..1933836	+	627	WP_000669024.1	hypothetical protein	-
GDK20_RS09475	1933877..1934218	+	342	WP_000627540.1	DUF3969 family protein	-
GDK20_RS09480	1934319..1934891	+	573	WP_000414216.1	hypothetical protein	-
GDK20_RS09485	1935089..1936101	-	1013	Protein_1827	IS3 family transposase	-
GDK20_RS09490	1936246..1936341	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1936369..1936426	-	58	-	-	Antitoxin
GDK20_RS09495	1936464..1936565	+	102	WP_001792025.1	hypothetical protein	-
GDK20_RS09500	1936543..1936704	-	162	Protein_1830	transposase	-
GDK20_RS09505	1936695..1937189	-	495	Protein_1831	transposase	-
GDK20_RS09510	1937641..1938870	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
GDK20_RS09515	1938863..1940419	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
GDK20_RS09520	1940583..1940717	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M)	lukD / hlgA / selk	1898436..1981029	82593

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T32740 WP_001801861.1 NZ_AP019545:1936246-1936341 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T32740 NZ_AP019545:1936246-1936341 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT32740 NZ_AP019545:c1936426-1936369 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin