Detailed information of TA system TA032737

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1598307..1598886
• Replicon: chromosome
• Accession: NZ_AP019545
• Organism: Staphylococcus aureus strain KG-22

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: GDK20_RS07800
• Protein ID: WP_001025401.1
• Coordinates: 1598641..1598886 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1598307..1598672 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GDK20_RS07760	1595050..1595607	-	558	WP_000645042.1	DUF2815 family protein	-
GDK20_RS07765	1595633..1596799	-	1167	WP_000762532.1	DUF2800 domain-containing protein	-
GDK20_RS07770	1596796..1597158	-	363	WP_152064739.1	hypothetical protein	-
GDK20_RS07775	1597173..1597496	-	324	WP_000174998.1	hypothetical protein	-
GDK20_RS07780	1597575..1597736	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
GDK20_RS07785	1597749..1598012	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
GDK20_RS07790	1598037..1598252	-	216	WP_001097552.1	hypothetical protein	-
GDK20_RS07795	1598307..1598672	+	366	WP_001128433.1	hypothetical protein	Antitoxin
GDK20_RS07800	1598641..1598886	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
GDK20_RS07805	1598942..1599151	+	210	WP_000642492.1	hypothetical protein	-
GDK20_RS07810	1599141..1599284	-	144	WP_000939498.1	hypothetical protein	-
GDK20_RS07815	1599313..1600089	-	777	WP_117206550.1	Rha family transcriptional regulator	-
GDK20_RS07820	1600112..1600339	-	228	WP_015978369.1	helix-turn-helix transcriptional regulator	-
GDK20_RS07825	1600493..1601125	+	633	WP_031915307.1	XRE family transcriptional regulator	-
GDK20_RS07830	1601141..1602061	+	921	WP_117206548.1	3'-5' exoribonuclease	-
GDK20_RS07835	1602157..1602339	+	183	WP_000705240.1	hypothetical protein	-
GDK20_RS07840	1602376..1602522	+	147	WP_117206547.1	hypothetical protein	-
GDK20_RS07845	1602519..1603133	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1557825..1622089	64264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T32737 WP_001025401.1 NZ_AP019545:c1598886-1598641 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T32737 NZ_AP019545:c1598886-1598641 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT32737 NZ_AP019545:1598307-1598672 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin