Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2600938..2601122 Replicon chromosome
Accession NZ_AP019543
Organism Staphylococcus aureus strain KG-18

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag GDK18_RS13340 Protein ID WP_000482652.1
Coordinates 2601015..2601122 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2600938..2600998 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDK18_RS13325 2596393..2596560 - 168 Protein_2512 hypothetical protein -
GDK18_RS13330 2596791..2598524 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
GDK18_RS13335 2598549..2600312 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2600938..2600998 + 61 - - Antitoxin
GDK18_RS13340 2601015..2601122 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
GDK18_RS13345 2601256..2601642 - 387 WP_000779360.1 flippase GtxA -
GDK18_RS13350 2601910..2603052 + 1143 WP_001176863.1 glycerate kinase -
GDK18_RS13355 2603112..2603771 + 660 WP_000831298.1 membrane protein -
GDK18_RS13360 2603953..2605164 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
GDK18_RS13365 2605287..2605760 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T32732 WP_000482652.1 NZ_AP019543:c2601122-2601015 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T32732 NZ_AP019543:c2601122-2601015 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT32732 NZ_AP019543:2600938-2600998 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References