Detailed information of TA system TA032718

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1936897..1937077
• Replicon: chromosome
• Accession: NZ_AP019543
• Organism: Staphylococcus aureus strain KG-18

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: GDK18_RS09485
• Protein ID: WP_001801861.1
• Coordinates: 1936897..1936992 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1937020..1937077 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GDK18_RS09455	1932060..1932710	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
GDK18_RS09460	1932791..1933786	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
GDK18_RS09465	1933861..1934487	+	627	WP_000669024.1	hypothetical protein	-
GDK18_RS09470	1934528..1934869	+	342	WP_000627540.1	DUF3969 family protein	-
GDK18_RS09475	1934970..1935542	+	573	WP_000414216.1	hypothetical protein	-
GDK18_RS09480	1935740..1936752	-	1013	Protein_1823	IS3 family transposase	-
GDK18_RS09485	1936897..1936992	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1937020..1937077	-	58	-	-	Antitoxin
GDK18_RS09490	1937115..1937216	+	102	WP_001792025.1	hypothetical protein	-
GDK18_RS09495	1937194..1937355	-	162	Protein_1826	transposase	-
GDK18_RS09500	1937346..1937840	-	495	Protein_1827	transposase	-
GDK18_RS09505	1938292..1939521	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
GDK18_RS09510	1939514..1941070	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
GDK18_RS09515	1941234..1941368	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M)	lukD / hlgA / selk	1896423..1981680	85257

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T32718 WP_001801861.1 NZ_AP019543:1936897-1936992 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T32718 NZ_AP019543:1936897-1936992 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT32718 NZ_AP019543:c1937077-1937020 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin