Detailed information of TA system TA032715

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1593630..1594209
• Replicon: chromosome
• Accession: NZ_AP019543
• Organism: Staphylococcus aureus strain KG-18

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: GDK18_RS07775
• Protein ID: WP_001025401.1
• Coordinates: 1593964..1594209 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1593630..1593995 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GDK18_RS07735	1590373..1590930	-	558	WP_000645042.1	DUF2815 family protein	-
GDK18_RS07740	1590956..1592122	-	1167	WP_000762532.1	DUF2800 domain-containing protein	-
GDK18_RS07745	1592119..1592481	-	363	WP_152064739.1	hypothetical protein	-
GDK18_RS07750	1592496..1592819	-	324	WP_000174998.1	hypothetical protein	-
GDK18_RS07755	1592898..1593059	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
GDK18_RS07760	1593072..1593335	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
GDK18_RS07765	1593360..1593575	-	216	WP_001097552.1	hypothetical protein	-
GDK18_RS07770	1593630..1593995	+	366	WP_001128433.1	hypothetical protein	Antitoxin
GDK18_RS07775	1593964..1594209	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
GDK18_RS07780	1594265..1594474	+	210	WP_000642492.1	hypothetical protein	-
GDK18_RS07785	1594464..1594607	-	144	WP_000939498.1	hypothetical protein	-
GDK18_RS07790	1594636..1595412	-	777	WP_117206550.1	Rha family transcriptional regulator	-
GDK18_RS07795	1595435..1595662	-	228	WP_015978369.1	helix-turn-helix transcriptional regulator	-
GDK18_RS07800	1595816..1596448	+	633	WP_031915307.1	XRE family transcriptional regulator	-
GDK18_RS07805	1596464..1597384	+	921	WP_117206548.1	3'-5' exoribonuclease	-
GDK18_RS07810	1597480..1597662	+	183	WP_000705240.1	hypothetical protein	-
GDK18_RS07815	1597699..1597845	+	147	WP_117206547.1	hypothetical protein	-
GDK18_RS07820	1597842..1598456	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1553148..1617412	64264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T32715 WP_001025401.1 NZ_AP019543:c1594209-1593964 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T32715 NZ_AP019543:c1594209-1593964 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT32715 NZ_AP019543:1593630-1593995 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin