Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2583034..2583218 Replicon chromosome
Accession NZ_AP019542
Organism Staphylococcus aureus strain KG-03

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag GDK21_RS13240 Protein ID WP_000482652.1
Coordinates 2583111..2583218 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2583034..2583094 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDK21_RS13225 2578489..2578656 - 168 Protein_2496 hypothetical protein -
GDK21_RS13230 2578887..2580620 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
GDK21_RS13235 2580645..2582408 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2583034..2583094 + 61 - - Antitoxin
GDK21_RS13240 2583111..2583218 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
GDK21_RS13245 2583352..2583738 - 387 WP_000779360.1 flippase GtxA -
GDK21_RS13250 2584006..2585148 + 1143 WP_001176863.1 glycerate kinase -
GDK21_RS13255 2585208..2585867 + 660 WP_000831298.1 membrane protein -
GDK21_RS13260 2586049..2587260 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
GDK21_RS13265 2587383..2587856 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T32710 WP_000482652.1 NZ_AP019542:c2583218-2583111 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T32710 NZ_AP019542:c2583218-2583111 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT32710 NZ_AP019542:2583034-2583094 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References