Detailed information of TA system TA032696

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1928418..1928598
• Replicon: chromosome
• Accession: NZ_AP019542
• Organism: Staphylococcus aureus strain KG-03

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: GDK21_RS09450
• Protein ID: WP_001801861.1
• Coordinates: 1928418..1928513 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1928541..1928598 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GDK21_RS09420	1923581..1924231	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
GDK21_RS09425	1924312..1925307	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
GDK21_RS09430	1925382..1926008	+	627	WP_000669024.1	hypothetical protein	-
GDK21_RS09435	1926049..1926390	+	342	WP_000627540.1	DUF3969 family protein	-
GDK21_RS09440	1926491..1927063	+	573	WP_000414216.1	hypothetical protein	-
GDK21_RS09445	1927261..1928273	-	1013	Protein_1820	IS3 family transposase	-
GDK21_RS09450	1928418..1928513	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1928541..1928598	-	58	-	-	Antitoxin
GDK21_RS09455	1928636..1928737	+	102	WP_001792025.1	hypothetical protein	-
GDK21_RS09460	1928715..1928876	-	162	Protein_1823	transposase	-
GDK21_RS09465	1928867..1929361	-	495	Protein_1824	transposase	-
GDK21_RS09470	1929813..1931042	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
GDK21_RS09475	1931035..1932591	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
GDK21_RS09480	1932755..1932889	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M)	lukD / hlgA / selk	1890608..1973201	82593

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T32696 WP_001801861.1 NZ_AP019542:1928418-1928513 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T32696 NZ_AP019542:1928418-1928513 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT32696 NZ_AP019542:c1928598-1928541 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin