Detailed information of TA system TA032693

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1593331..1593910
• Replicon: chromosome
• Accession: NZ_AP019542
• Organism: Staphylococcus aureus strain KG-03

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: GDK21_RS07780
• Protein ID: WP_001025401.1
• Coordinates: 1593665..1593910 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1593331..1593696 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GDK21_RS07740	1590074..1590631	-	558	WP_000645042.1	DUF2815 family protein	-
GDK21_RS07745	1590657..1591823	-	1167	WP_000762532.1	DUF2800 domain-containing protein	-
GDK21_RS07750	1591820..1592182	-	363	WP_152064739.1	hypothetical protein	-
GDK21_RS07755	1592197..1592520	-	324	WP_000174998.1	hypothetical protein	-
GDK21_RS07760	1592599..1592760	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
GDK21_RS07765	1592773..1593036	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
GDK21_RS07770	1593061..1593276	-	216	WP_001097552.1	hypothetical protein	-
GDK21_RS07775	1593331..1593696	+	366	WP_001128433.1	hypothetical protein	Antitoxin
GDK21_RS07780	1593665..1593910	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
GDK21_RS07785	1593966..1594175	+	210	WP_000642492.1	hypothetical protein	-
GDK21_RS07790	1594165..1594308	-	144	WP_000939498.1	hypothetical protein	-
GDK21_RS07795	1594337..1595113	-	777	WP_117206550.1	Rha family transcriptional regulator	-
GDK21_RS07800	1595136..1595363	-	228	WP_015978369.1	helix-turn-helix transcriptional regulator	-
GDK21_RS07805	1595517..1596149	+	633	WP_031915307.1	XRE family transcriptional regulator	-
GDK21_RS07810	1596165..1597085	+	921	WP_117206548.1	3'-5' exoribonuclease	-
GDK21_RS07815	1597181..1597363	+	183	WP_000705240.1	hypothetical protein	-
GDK21_RS07820	1597400..1597546	+	147	WP_117206547.1	hypothetical protein	-
GDK21_RS07825	1597543..1598157	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1552851..1617113	64262

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T32693 WP_001025401.1 NZ_AP019542:c1593910-1593665 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T32693 NZ_AP019542:c1593910-1593665 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT32693 NZ_AP019542:1593331-1593696 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin