Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2626351..2627108 Replicon chromosome
Accession NZ_AP019531
Organism Serratia symbiotica strain IS

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SSYIS1_RS13325 Protein ID WP_037388000.1
Coordinates 2626791..2627108 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SSYIS1_RS13320 Protein ID WP_172624213.1
Coordinates 2626351..2626752 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSYIS1_RS13295 2621612..2622850 + 1239 Protein_2537 enterobactin transporter EntS -
SSYIS1_RS13300 2622851..2623066 - 216 WP_006708086.1 hypothetical protein -
SSYIS1_RS13305 2623066..2623389 - 324 WP_149590913.1 hypothetical protein -
SSYIS1_RS13310 2623467..2624979 - 1513 Protein_2540 hypothetical protein -
SSYIS1_RS13315 2624972..2626159 - 1188 Protein_2541 HlyD family secretion protein -
SSYIS1_RS13320 2626351..2626752 - 402 WP_172624213.1 helix-turn-helix domain-containing protein Antitoxin
SSYIS1_RS13325 2626791..2627108 - 318 WP_037388000.1 type II toxin-antitoxin system HigB family toxin Toxin
SSYIS1_RS13330 2627989..2629197 + 1209 Protein_2544 IS256 family transposase -
SSYIS1_RS13340 2629250..2630290 + 1041 WP_149590914.1 hypothetical protein -
SSYIS1_RS13345 2630247..2630576 + 330 WP_149590915.1 hypothetical protein -
SSYIS1_RS13350 2630593..2631597 + 1005 WP_006709383.1 IpaD/SipD/SspD family type III secretion system needle tip protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2623066..2634007 10941


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(24-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12446.40 Da        Isoelectric Point: 10.0787

>T32662 WP_037388000.1 NZ_AP019531:c2627108-2626791 [Serratia symbiotica]
IRGACDSRQPFNEAAGKYPNSALALLYLMRVLEKKTFNSPDEMKRAIPSLDNFKYRKKWWVIDVSGNTVRLMAFIDFEKQ
KVFVKHIATHAEYDKLTKYYREHKE

Download         Length: 318 bp

>T32662 NZ_AP019531:c2627108-2626791 [Serratia symbiotica]
ATTCGCGGTGCATGTGACAGCAGACAACCGTTTAATGAGGCTGCCGGGAAATACCCTAATAGCGCGTTGGCGCTTCTGTA
TCTGATGAGGGTTCTGGAAAAAAAAACCTTCAACAGTCCGGATGAGATGAAAAGAGCAATCCCTTCACTGGATAACTTCA
AGTACCGAAAAAAGTGGTGGGTCATCGATGTGTCCGGTAACACAGTGCGGCTGATGGCCTTCATTGACTTTGAAAAGCAA
AAGGTTTTTGTTAAGCACATTGCGACTCATGCCGAATACGATAAGTTAACCAAGTATTATAGGGAGCATAAAGAATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14640.81 Da        Isoelectric Point: 4.7680

>AT32662 WP_172624213.1 NZ_AP019531:c2626752-2626351 [Serratia symbiotica]
MIATFANAVKCIPLMTGDKSEAEYNKALELIEYLVDRDELSNPLFEPLAAKITEYENSAPEFEAFNRRLAEIPTGVAALR
TLMDQNGLKAADLIDELGSKSNVSNILSGRRALTVKHIKALASRFNVPADLFI

Download         Length: 402 bp

>AT32662 NZ_AP019531:c2626752-2626351 [Serratia symbiotica]
ATGATCGCGACATTTGCCAACGCGGTGAAATGCATTCCTCTAATGACGGGTGATAAAAGCGAGGCTGAATATAACAAAGC
CCTTGAGCTGATTGAATATCTTGTCGATCGCGACGAGCTGAGCAACCCGCTTTTTGAACCGCTTGCGGCCAAAATTACAG
AATATGAAAACAGCGCCCCGGAATTTGAGGCGTTTAACCGTCGCTTGGCTGAGATCCCTACCGGGGTCGCCGCGTTGCGT
ACCCTGATGGATCAGAATGGTTTAAAAGCGGCTGATCTGATTGACGAACTGGGATCTAAAAGCAATGTCAGTAACATTCT
CAGTGGTCGCCGCGCATTGACCGTGAAGCACATTAAGGCGTTGGCATCGCGTTTTAACGTTCCCGCTGATTTGTTTATTT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References