32656

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 976333..976841 Replicon chromosome
Accession NZ_AP019531
Organism Serratia symbiotica strain IS

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7X3T0F2
Locus tag SSYIS1_RS05060 Protein ID WP_071985748.1
Coordinates 976575..976841 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E9CKE8
Locus tag SSYIS1_RS05055 Protein ID WP_006708173.1
Coordinates 976333..976578 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSYIS1_RS05030 971539..972471 + 933 Protein_968 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
SSYIS1_RS05035 972471..974186 + 1716 WP_149590638.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
SSYIS1_RS05040 974404..975132 + 729 WP_006708172.1 phosphoadenylyl-sulfate reductase -
SSYIS1_RS05050 975445..976071 + 627 WP_050789064.1 hypothetical protein -
SSYIS1_RS05055 976333..976578 + 246 WP_006708173.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SSYIS1_RS05060 976575..976841 + 267 WP_071985748.1 Txe/YoeB family addiction module toxin Toxin
SSYIS1_RS05065 976946..977287 + 342 WP_037388119.1 hypothetical protein -
SSYIS1_RS05070 977596..977916 + 321 WP_006708174.1 cell division protein FtsB -
SSYIS1_RS05075 977920..978627 + 708 WP_006708175.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
SSYIS1_RS05080 978638..979111 + 474 WP_149590639.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
SSYIS1_RS05085 979116..980153 + 1038 WP_006708177.1 tRNA pseudouridine(13) synthase TruD -
SSYIS1_RS05090 980131..980892 + 762 WP_006708178.1 5'/3'-nucleotidase SurE -
SSYIS1_RS05095 980899..981525 + 627 WP_006708179.1 protein-L-isoaspartate(D-aspartate) O-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 946566..988758 42192


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10572.24 Da        Isoelectric Point: 10.5562

>T32656 WP_071985748.1 NZ_AP019531:976575-976841 [Serratia symbiotica]
MKIRFTRRAATDFQYWQKNNVKVYERVRLLIKAAHADPFCGIGKPERLRHHKNPALYSRRIDREHRLVYSVTDGELTIIA
CRFHYESL

Download         Length: 267 bp

>T32656 NZ_AP019531:976575-976841 [Serratia symbiotica]
TTGAAGATCCGGTTTACCCGACGGGCTGCCACCGATTTCCAATACTGGCAGAAAAACAACGTCAAGGTATACGAACGCGT
TCGATTGCTGATCAAGGCTGCTCACGCTGATCCGTTTTGTGGTATCGGAAAGCCTGAGCGGCTTCGTCACCACAAAAATC
CTGCGCTGTATTCACGCCGTATAGACAGGGAACATAGACTCGTTTATAGCGTCACTGACGGTGAGTTAACGATAATTGCC
TGCCGCTTTCACTACGAAAGCCTCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9123.26 Da        Isoelectric Point: 4.6069

>AT32656 WP_006708173.1 NZ_AP019531:976333-976578 [Serratia symbiotica]
MHALTFTDARKHFAETMQRVSDNAEPVRILRRDAPDVIIIGAHEYDAMVETLHLFSNPVNAAHINASLDELERGDIVEID
V

Download         Length: 246 bp

>AT32656 NZ_AP019531:976333-976578 [Serratia symbiotica]
ATGCATGCATTAACGTTCACAGACGCGAGGAAACACTTCGCCGAGACAATGCAGCGCGTCAGTGACAACGCCGAGCCGGT
ACGCATCTTGCGACGTGATGCCCCTGACGTCATCATCATTGGTGCCCATGAATACGACGCTATGGTTGAAACGCTACACC
TTTTCAGCAATCCGGTGAACGCCGCCCATATCAATGCGTCTCTGGATGAACTAGAACGCGGGGATATCGTCGAGATTGAC
GTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X3T0F2

Antitoxin

Source ID Structure
AlphaFold DB A0A068YWA6

References