Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 290715..291234 Replicon chromosome
Accession NZ_AP019314
Organism Microcystis viridis NIES-102

Toxin (Protein)


Gene name yoeB Uniprot ID I4HB24
Locus tag myaer102_RS01455 Protein ID WP_002756029.1
Coordinates 290968..291234 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID L7E5D8
Locus tag myaer102_RS01450 Protein ID WP_002736246.1
Coordinates 290715..290975 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
myaer102_RS01415 285724..286086 + 363 WP_002756992.1 hypothetical protein -
myaer102_RS01420 286086..286778 + 693 WP_125730225.1 7-cyano-7-deazaguanine synthase QueC -
myaer102_RS01425 286805..287377 - 573 WP_012265686.1 manganese efflux pump MntP family protein -
myaer102_RS30400 287686..287856 - 171 WP_148204743.1 alpha-ketoglutarate-dependent dioxygenase AlkB -
myaer102_RS01435 288056..289009 + 954 WP_012265688.1 branched-chain amino acid ABC transporter permease -
myaer102_RS01440 289101..290012 + 912 WP_012265689.1 hypothetical protein -
myaer102_RS01450 290715..290975 + 261 WP_002736246.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
myaer102_RS01455 290968..291234 + 267 WP_002756029.1 Txe/YoeB family addiction module toxin Toxin
myaer102_RS01460 291476..292237 - 762 WP_125732662.1 PEP-CTERM sorting domain-containing protein -
myaer102_RS01465 292517..292744 - 228 WP_125730226.1 hypothetical protein -
myaer102_RS01480 293114..294598 + 1485 WP_012264152.1 IS1380-like element ISMae9 family transposase -
myaer102_RS01485 294813..295019 - 207 WP_125730227.1 DUF4926 domain-containing protein -
myaer102_RS01490 295026..295241 - 216 Protein_277 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10459.08 Da        Isoelectric Point: 9.9458

>T32624 WP_002756029.1 NZ_AP019314:290968-291234 [Microcystis viridis NIES-102]
MDNWQLVFTKQAKKDAEKLARTGLAKQANELLNILKSNPYQSYPVYEKLSGDLASYYSRRINIQHRLVYQVIPEEKVVKV
IRMWTHYE

Download         Length: 267 bp

>T32624 NZ_AP019314:290968-291234 [Microcystis viridis NIES-102]
ATGGATAATTGGCAGTTGGTTTTTACCAAACAAGCGAAAAAAGATGCTGAAAAGCTGGCTCGTACTGGGTTGGCAAAACA
AGCTAACGAGTTATTAAATATTCTTAAGTCAAATCCGTATCAATCTTATCCTGTTTATGAGAAACTCAGTGGCGATTTAG
CGAGCTATTATTCCAGACGTATTAATATTCAGCATCGTTTGGTTTATCAGGTTATTCCAGAAGAGAAGGTTGTCAAAGTT
ATACGGATGTGGACTCATTATGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9432.56 Da        Isoelectric Point: 3.8305

>AT32624 WP_002736246.1 NZ_AP019314:290715-290975 [Microcystis viridis NIES-102]
MKIVTVTEAKEQIDELVNDTNDNHQPILLSGTKKNAILIAEEDWNSIQETLYLYSIPGMVDSIIEGGNTSIEDCVDEAGI
RAILNG

Download         Length: 261 bp

>AT32624 NZ_AP019314:290715-290975 [Microcystis viridis NIES-102]
ATGAAAATTGTTACTGTTACTGAAGCCAAAGAACAAATTGATGAATTAGTGAATGATACCAATGATAATCATCAACCAAT
TTTGTTATCTGGTACGAAAAAGAATGCTATTTTAATTGCTGAGGAAGATTGGAACTCTATTCAAGAAACGCTTTATTTGT
ATTCTATTCCTGGTATGGTAGATTCAATTATTGAAGGTGGCAACACTTCTATTGAAGATTGTGTGGATGAGGCGGGTATC
AGAGCAATTTTAAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822LG33

Antitoxin

Source ID Structure
AlphaFold DB L7E5D8

References