Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1120696..1121271 Replicon chromosome
Accession NZ_AP019307
Organism Nocardioides baekrokdamisoli strain KCTC 39748

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KCTC_RS05360 Protein ID WP_125567456.1
Coordinates 1120993..1121271 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag KCTC_RS05355 Protein ID WP_125567454.1
Coordinates 1120696..1120980 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCTC_RS05325 1116625..1117062 - 438 WP_125567442.1 hypothetical protein -
KCTC_RS05330 1117062..1117898 - 837 WP_164512485.1 acyltransferase family protein -
KCTC_RS05335 1118054..1119427 + 1374 WP_125567446.1 MFS transporter -
KCTC_RS05340 1119457..1119720 - 264 WP_125567448.1 type II toxin-antitoxin system RelE/ParE family toxin -
KCTC_RS05345 1119717..1119998 - 282 WP_197715257.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KCTC_RS05350 1120047..1120544 - 498 WP_125567452.1 DUF1877 family protein -
KCTC_RS05355 1120696..1120980 - 285 WP_125567454.1 HigA family addiction module antidote protein Antitoxin
KCTC_RS05360 1120993..1121271 - 279 WP_125567456.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KCTC_RS05365 1121348..1122754 + 1407 WP_125567458.1 recombinase family protein -
KCTC_RS05370 1123250..1123492 + 243 WP_197715258.1 hypothetical protein -
KCTC_RS05375 1123489..1125519 + 2031 WP_125567460.1 AAA family ATPase -
KCTC_RS05380 1125784..1126059 - 276 WP_197715259.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10572.01 Da        Isoelectric Point: 6.2098

>T32614 WP_125567456.1 NZ_AP019307:c1121271-1120993 [Nocardioides baekrokdamisoli]
VIVTFRHEGLEALFRTGSKRGVQPSHAPKLLRMLDLIDVASEPADVMLPGYRAHELHGDLAGHWSMWVNGNWRVTFRFIG
EDVELVDYQDYH

Download         Length: 279 bp

>T32614 NZ_AP019307:c1121271-1120993 [Nocardioides baekrokdamisoli]
GTGATCGTCACCTTCCGTCACGAGGGACTTGAGGCGTTGTTTCGCACCGGGTCCAAGCGGGGAGTGCAGCCCAGCCATGC
ACCGAAACTGTTGCGCATGCTCGACCTCATCGACGTTGCGTCCGAGCCGGCCGACGTCATGCTTCCGGGCTACCGGGCGC
ACGAACTTCACGGAGATCTGGCCGGGCACTGGTCGATGTGGGTGAACGGCAACTGGCGGGTCACGTTCAGATTCATCGGC
GAGGACGTCGAACTCGTCGACTATCAGGACTATCACTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 9974.57 Da        Isoelectric Point: 7.4723

>AT32614 WP_125567454.1 NZ_AP019307:c1120980-1120696 [Nocardioides baekrokdamisoli]
MVVRIPTHPGAILREDVLPELGLSVSAVAEHLGVSRVTLSRVLHEHSAISPNLALRLEAAGLSSARVWLAMQSAHDLAAE
RKAGIPKVETLQSA

Download         Length: 285 bp

>AT32614 NZ_AP019307:c1120980-1120696 [Nocardioides baekrokdamisoli]
ATGGTTGTACGGATCCCGACTCATCCGGGCGCGATCCTCCGTGAGGACGTATTGCCCGAACTTGGGCTCAGCGTCTCGGC
TGTGGCGGAGCACCTGGGAGTGTCGCGCGTGACGCTGAGCCGCGTACTTCATGAGCACTCGGCGATCTCGCCCAACCTCG
CCCTCCGTCTGGAGGCTGCAGGGCTGAGCAGTGCGCGGGTGTGGCTCGCCATGCAGAGCGCCCACGACCTCGCTGCCGAA
CGCAAGGCAGGCATTCCGAAGGTCGAAACGCTTCAGTCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References