Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1165665..1166182 Replicon chromosome
Accession NZ_AP019306
Organism Staphylococcus aureus strain TUM9463

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag EKM74_RS06500 Protein ID WP_000113265.1
Coordinates 1165665..1165931 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag EKM74_RS06505 Protein ID WP_000584499.1
Coordinates 1165931..1166182 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKM74_RS06470 1161093..1161629 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
EKM74_RS06475 1161863..1162687 - 825 WP_000572038.1 formate/nitrite transporter family protein -
EKM74_RS06480 1162904..1163086 - 183 WP_000230292.1 hypothetical protein -
EKM74_RS06485 1163170..1163637 - 468 WP_000153347.1 SRPBCC domain-containing protein -
EKM74_RS06490 1163823..1165370 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EKM74_RS06495 1165559..1165630 - 72 Protein_1187 hypothetical protein -
EKM74_RS06500 1165665..1165931 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
EKM74_RS06505 1165931..1166182 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EKM74_RS06510 1166347..1166448 - 102 Protein_1190 hypothetical protein -
EKM74_RS06515 1166455..1167054 - 600 WP_000162810.1 DsbA family protein -
EKM74_RS06520 1167073..1167435 - 363 WP_000819843.1 DUF4467 domain-containing protein -
EKM74_RS06525 1167690..1168940 + 1251 WP_125571294.1 FemA/FemB family glycyltransferase FmhA -
EKM74_RS06530 1169037..1169768 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
EKM74_RS06535 1169765..1170484 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T32604 WP_000113265.1 NZ_AP019306:c1165931-1165665 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T32604 NZ_AP019306:c1165931-1165665 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT32604 WP_000584499.1 NZ_AP019306:c1166182-1165931 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT32604 NZ_AP019306:c1166182-1165931 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References