Detailed information of TA system TA032590

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 502295..502475
• Replicon: chromosome
• Accession: NZ_AP019306
• Organism: Staphylococcus aureus strain TUM9463

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: EKM74_RS02530
• Protein ID: WP_001801861.1
• Coordinates: 502295..502390 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	502418..502475 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EKM74_RS02500	497590..498240	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
EKM74_RS02505	498321..499316	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
EKM74_RS02510	499391..500017	+	627	WP_000669024.1	hypothetical protein	-
EKM74_RS02515	500058..500399	+	342	WP_000627540.1	DUF3969 family protein	-
EKM74_RS02520	500500..501072	+	573	WP_000414216.1	hypothetical protein	-
EKM74_RS02525	501270..502150	-	881	Protein_486	IS3 family transposase	-
EKM74_RS02530	502295..502390	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	502418..502475	-	58	-	-	Antitoxin
EKM74_RS02535	502513..502614	+	102	WP_001792025.1	hypothetical protein	-
EKM74_RS02540	502592..502753	-	162	Protein_489	transposase	-
EKM74_RS02545	502744..503238	-	495	Protein_490	transposase	-
EKM74_RS02550	503690..504919	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
EKM74_RS02555	504912..506468	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	496832..575367	78535
	-	flank	IS/Tn	-	-	506678..507850	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T32590 WP_001801861.1 NZ_AP019306:502295-502390 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T32590 NZ_AP019306:502295-502390 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT32590 NZ_AP019306:c502475-502418 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin