Detailed information of TA system TA032587

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 157285..157864
• Replicon: chromosome
• Accession: NZ_AP019306
• Organism: Staphylococcus aureus strain TUM9463

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: EKM74_RS00740
• Protein ID: WP_001025401.1
• Coordinates: 157619..157864 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	157285..157650 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EKM74_RS00700	154029..154586	-	558	WP_000645045.1	DUF2815 family protein	-
EKM74_RS00705	154612..155778	-	1167	WP_000762525.1	DUF2800 domain-containing protein	-
EKM74_RS00710	155775..156137	-	363	WP_000279445.1	hypothetical protein	-
EKM74_RS00715	156152..156475	-	324	WP_000174995.1	hypothetical protein	-
EKM74_RS00720	156554..156715	-	162	WP_015986189.1	DUF1270 family protein	-
EKM74_RS00725	156727..156990	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
EKM74_RS00730	157015..157230	-	216	WP_001097552.1	hypothetical protein	-
EKM74_RS00735	157285..157650	+	366	WP_001128433.1	hypothetical protein	Antitoxin
EKM74_RS00740	157619..157864	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
EKM74_RS00745	157920..158129	+	210	WP_000642492.1	hypothetical protein	-
EKM74_RS00750	158119..158262	-	144	WP_000939498.1	hypothetical protein	-
EKM74_RS00755	158277..158720	-	444	WP_000435360.1	hypothetical protein	-
EKM74_RS00760	158738..158962	-	225	WP_063653167.1	DUF739 family protein	-
EKM74_RS00765	159124..159504	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
EKM74_RS00770	159526..159984	+	459	WP_001558059.1	hypothetical protein	-
EKM74_RS00775	160002..160323	+	322	Protein_148	hypothetical protein	-
EKM74_RS00780	160352..160747	+	396	WP_000449655.1	hypothetical protein	-
EKM74_RS00785	160837..160983	+	147	WP_001795334.1	hypothetical protein	-
EKM74_RS00790	160980..161594	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	114218..181616	67398

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T32587 WP_001025401.1 NZ_AP019306:c157864-157619 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T32587 NZ_AP019306:c157864-157619 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT32587 NZ_AP019306:157285-157650 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin