Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1172319..1172836 Replicon chromosome
Accession NZ_AP019305
Organism Staphylococcus aureus strain TUM9458

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag EKM72_RS06535 Protein ID WP_000113265.1
Coordinates 1172319..1172585 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag EKM72_RS06540 Protein ID WP_000584499.1
Coordinates 1172585..1172836 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKM72_RS06505 1167747..1168283 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
EKM72_RS06510 1168517..1169341 - 825 WP_000572038.1 formate/nitrite transporter family protein -
EKM72_RS06515 1169558..1169740 - 183 WP_000230292.1 hypothetical protein -
EKM72_RS06520 1169824..1170291 - 468 WP_000153347.1 SRPBCC domain-containing protein -
EKM72_RS06525 1170477..1172024 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EKM72_RS06530 1172213..1172284 - 72 Protein_1196 hypothetical protein -
EKM72_RS06535 1172319..1172585 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
EKM72_RS06540 1172585..1172836 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EKM72_RS06545 1173001..1173102 - 102 Protein_1199 hypothetical protein -
EKM72_RS06550 1173109..1173708 - 600 WP_000162810.1 DsbA family protein -
EKM72_RS06555 1173727..1174089 - 363 WP_000819843.1 DUF4467 domain-containing protein -
EKM72_RS06560 1174344..1175594 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
EKM72_RS06565 1175691..1176422 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
EKM72_RS06570 1176419..1177138 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T32580 WP_000113265.1 NZ_AP019305:c1172585-1172319 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T32580 NZ_AP019305:c1172585-1172319 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT32580 WP_000584499.1 NZ_AP019305:c1172836-1172585 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT32580 NZ_AP019305:c1172836-1172585 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References