Detailed information of TA system TA032566

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 503361..503541
• Replicon: chromosome
• Accession: NZ_AP019305
• Organism: Staphylococcus aureus strain TUM9458

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: EKM72_RS02535
• Protein ID: WP_001801861.1
• Coordinates: 503361..503456 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	503484..503541 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EKM72_RS02505	498656..499306	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
EKM72_RS02510	499387..500382	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
EKM72_RS02515	500457..501083	+	627	WP_000669024.1	hypothetical protein	-
EKM72_RS02520	501124..501465	+	342	WP_000627540.1	DUF3969 family protein	-
EKM72_RS02525	501566..502138	+	573	WP_000414216.1	hypothetical protein	-
EKM72_RS02530	502336..503216	-	881	Protein_487	IS3 family transposase	-
EKM72_RS02535	503361..503456	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	503484..503541	-	58	-	-	Antitoxin
EKM72_RS02540	503579..503680	+	102	WP_001792025.1	hypothetical protein	-
EKM72_RS02545	503658..503819	-	162	Protein_490	transposase	-
EKM72_RS02550	503810..504304	-	495	Protein_491	transposase	-
EKM72_RS02555	504756..505985	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
EKM72_RS02560	505978..507534	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	497898..576433	78535
	-	flank	IS/Tn	-	-	507744..508916	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T32566 WP_001801861.1 NZ_AP019305:503361-503456 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T32566 NZ_AP019305:503361-503456 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT32566 NZ_AP019305:c503541-503484 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin