Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1667139..1667651 Replicon chromosome
Accession NZ_AP019192
Organism Streptococcus pneumoniae strain ASP0581

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EL334_RS08885 Protein ID WP_000924721.1
Coordinates 1667139..1667393 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag EL334_RS08890 Protein ID WP_000388572.1
Coordinates 1667397..1667651 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL334_RS08870 1664240..1664554 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EL334_RS08875 1664579..1665205 - 627 WP_000775037.1 guanylate kinase -
EL334_RS08880 1665335..1666948 - 1614 WP_000404940.1 ribonuclease Y -
EL334_RS08885 1667139..1667393 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EL334_RS08890 1667397..1667651 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL334_RS08895 1667889..1668986 - 1098 WP_033705298.1 nucleotidyltransferase -
EL334_RS08900 1668996..1669742 - 747 WP_078375978.1 class I SAM-dependent methyltransferase -
EL334_RS08905 1669845..1670198 - 354 WP_001003001.1 ribosome silencing factor -
EL334_RS08910 1670211..1670711 - 501 WP_000844707.1 cysteine hydrolase -
EL334_RS08915 1670712..1671305 - 594 WP_000121654.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EL334_RS08920 1671305..1671934 - 630 WP_000151307.1 nicotinate-nucleotide adenylyltransferase -
EL334_RS08925 1671986..1672297 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T32555 WP_000924721.1 NZ_AP019192:c1667393-1667139 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T32555 NZ_AP019192:c1667393-1667139 [Streptococcus pneumoniae]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT32555 WP_000388572.1 NZ_AP019192:c1667651-1667397 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT32555 NZ_AP019192:c1667651-1667397 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References