32529

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 721986..722679 Replicon chromosome
Accession NZ_AP019189
Organism Escherichia coli strain M217

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag B7R44_RS04190 Protein ID WP_000415584.1
Coordinates 721986..722282 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag B7R44_RS04195 Protein ID WP_000650107.1
Coordinates 722284..722679 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7R44_RS04155 717074..717388 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
B7R44_RS04160 717419..718000 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
B7R44_RS04165 718319..718651 + 333 WP_000917685.1 DUF2645 family protein -
B7R44_RS04170 718697..720046 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
B7R44_RS04175 720043..720702 - 660 WP_001221493.1 two-component system response regulator QseB -
B7R44_RS04180 720854..721246 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
B7R44_RS04185 721299..721781 + 483 WP_000183505.1 transcriptional regulator -
B7R44_RS04190 721986..722282 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
B7R44_RS04195 722284..722679 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
B7R44_RS04200 722812..724419 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
B7R44_RS04205 724557..726815 + 2259 WP_032329482.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T32529 WP_000415584.1 NZ_AP019189:721986-722282 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T32529 NZ_AP019189:721986-722282 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT32529 WP_000650107.1 NZ_AP019189:722284-722679 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT32529 NZ_AP019189:722284-722679 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References