Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3283429..3284089 Replicon chromosome
Accession NZ_AP019009
Organism Serratia marcescens strain AS-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SERAS_RS15730 Protein ID WP_016927037.1
Coordinates 3283736..3284089 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag SERAS_RS15725 Protein ID WP_016927038.1
Coordinates 3283429..3283731 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS_RS15705 3279045..3279959 - 915 WP_048797036.1 branched-chain amino acid ABC transporter permease -
SERAS_RS15710 3280083..3281201 - 1119 WP_048797037.1 branched-chain amino acid ABC transporter substrate-binding protein -
SERAS_RS15720 3281806..3283014 - 1209 WP_117286654.1 aldose 1-epimerase family protein -
SERAS_RS15725 3283429..3283731 - 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
SERAS_RS15730 3283736..3284089 - 354 WP_016927037.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SERAS_RS15735 3284528..3285823 + 1296 WP_028127724.1 MFS transporter -
SERAS_RS15740 3285851..3286657 + 807 WP_048796852.1 substrate-binding domain-containing protein -
SERAS_RS15745 3286632..3287531 - 900 WP_097101693.1 LysR family transcriptional regulator -
SERAS_RS15750 3287635..3288000 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13433.33 Da        Isoelectric Point: 8.4803

>T32505 WP_016927037.1 NZ_AP019009:c3284089-3283736 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDGMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

>T32505 NZ_AP019009:c3284089-3283736 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCACTCAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGTTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGTGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATGGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT32505 WP_016927038.1 NZ_AP019009:c3283731-3283429 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT32505 NZ_AP019009:c3283731-3283429 [Serratia marcescens]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATTGAACTGCCGGACGGCTCTCACTACGAGTTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References