32468

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1643506..1644018 Replicon chromosome
Accession NZ_AP018936
Organism Streptococcus pneumoniae strain NU83127

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EL277_RS08680 Protein ID WP_000924721.1
Coordinates 1643506..1643760 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag EL277_RS08685 Protein ID WP_000388572.1
Coordinates 1643764..1644018 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL277_RS08665 1640607..1640921 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EL277_RS08670 1640946..1641572 - 627 WP_000775037.1 guanylate kinase -
EL277_RS08675 1641702..1643315 - 1614 WP_000404940.1 ribonuclease Y -
EL277_RS08680 1643506..1643760 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EL277_RS08685 1643764..1644018 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL277_RS08690 1644256..1645353 - 1098 WP_000156358.1 nucleotidyltransferase -
EL277_RS08695 1645363..1646109 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
EL277_RS08700 1646212..1646565 - 354 WP_001003023.1 ribosome silencing factor -
EL277_RS08705 1646578..1647078 - 501 WP_000844707.1 cysteine hydrolase -
EL277_RS08710 1647079..1647672 - 594 WP_000121667.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EL277_RS08715 1647672..1648301 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
EL277_RS08720 1648353..1648664 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T32468 WP_000924721.1 NZ_AP018936:c1643760-1643506 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T32468 NZ_AP018936:c1643760-1643506 [Streptococcus pneumoniae]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT32468 WP_000388572.1 NZ_AP018936:c1644018-1643764 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT32468 NZ_AP018936:c1644018-1643764 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References