Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2548646..2548830 Replicon chromosome
Accession NZ_AP018923
Organism Staphylococcus aureus strain JMUB3031

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag D5070_RS13415 Protein ID WP_000482647.1
Coordinates 2548723..2548830 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2548646..2548706 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5070_RS13390 2544120..2544287 - 168 WP_001790576.1 hypothetical protein -
D5070_RS13400 2544518..2546251 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
D5070_RS13405 2546276..2548039 - 1764 WP_001064816.1 ABC transporter ATP-binding protein/permease -
- 2548646..2548706 + 61 - - Antitoxin
D5070_RS13415 2548723..2548830 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
D5070_RS13420 2548964..2549350 - 387 WP_000779360.1 flippase GtxA -
D5070_RS13425 2549608..2550750 + 1143 WP_001176871.1 glycerate kinase -
D5070_RS13430 2550810..2551469 + 660 WP_000831301.1 membrane protein -
D5070_RS13435 2551651..2552862 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
D5070_RS13440 2552985..2553458 - 474 WP_000456497.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(23-64)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T32454 WP_000482647.1 NZ_AP018923:c2548830-2548723 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T32454 NZ_AP018923:c2548830-2548723 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT32454 NZ_AP018923:2548646-2548706 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References