Detailed information of TA system TA032442

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1936200..1936382
• Replicon: chromosome
• Accession: NZ_AP018923
• Organism: Staphylococcus aureus strain JMUB3031

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: D5070_RS09860
• Protein ID: WP_001801861.1
• Coordinates: 1936200..1936295 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1936323..1936382 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5070_RS09810	1931870..1932496	+	627	WP_000669017.1	hypothetical protein	-
D5070_RS09815	1932537..1932878	+	342	WP_000627541.1	DUF3969 family protein	-
D5070_RS09820	1932979..1933551	+	573	WP_000414202.1	hypothetical protein	-
D5070_RS09825	1933749..1934306	-	558	Protein_1848	ImmA/IrrE family metallo-endopeptidase	-
D5070_RS09835	1934680..1934856	-	177	WP_000375477.1	hypothetical protein	-
D5070_RS09840	1934867..1935250	-	384	Protein_1850	hypothetical protein	-
D5070_RS09850	1935854..1935997	-	144	WP_001549059.1	transposase	-
D5070_RS09860	1936200..1936295	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1936323..1936382	-	60	-	-	Antitoxin
D5070_RS09865	1936418..1936519	+	102	WP_001791893.1	hypothetical protein	-
D5070_RS09870	1936497..1936673	-	177	Protein_1854	transposase	-
D5070_RS09875	1936867..1937244	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1929519..1990956	61437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T32442 WP_001801861.1 NZ_AP018923:1936200-1936295 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T32442 NZ_AP018923:1936200-1936295 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT32442 NZ_AP018923:c1936382-1936323 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin