Detailed information of TA system TA032438

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1604543..1605122
• Replicon: chromosome
• Accession: NZ_AP018923
• Organism: Staphylococcus aureus strain JMUB3031

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: D5070_RS08125
• Protein ID: WP_001025401.1
• Coordinates: 1604877..1605122 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1604543..1604908 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5070_RS08085	1601286..1601843	-	558	WP_000645045.1	DUF2815 family protein	-
D5070_RS08090	1601869..1603035	-	1167	WP_064129389.1	DUF2800 domain-containing protein	-
D5070_RS08095	1603032..1603394	-	363	WP_000985976.1	hypothetical protein	-
D5070_RS08100	1603409..1603732	-	324	WP_000174994.1	hypothetical protein	-
D5070_RS08105	1603811..1603972	-	162	WP_001285963.1	DUF1270 family protein	-
D5070_RS08110	1603985..1604248	-	264	WP_001124159.1	helix-turn-helix domain-containing protein	-
D5070_RS08115	1604273..1604488	-	216	WP_001097552.1	hypothetical protein	-
D5070_RS08120	1604543..1604908	+	366	WP_001128433.1	hypothetical protein	Antitoxin
D5070_RS08125	1604877..1605122	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
D5070_RS08130	1605178..1605387	+	210	WP_000642492.1	hypothetical protein	-
D5070_RS08135	1605377..1605520	-	144	WP_000939498.1	hypothetical protein	-
D5070_RS08140	1605549..1606325	-	777	WP_001148544.1	Rha family transcriptional regulator	-
D5070_RS08145	1606339..1606575	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
D5070_RS08150	1606727..1607041	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
D5070_RS08155	1607054..1607515	+	462	WP_000525004.1	hypothetical protein	-
D5070_RS08160	1607533..1608117	+	585	WP_000825948.1	hypothetical protein	-
D5070_RS08165	1608347..1608493	+	147	WP_072433242.1	hypothetical protein	-
D5070_RS08170	1608490..1609104	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1564908..1629793	64885

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T32438 WP_001025401.1 NZ_AP018923:c1605122-1604877 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T32438 NZ_AP018923:c1605122-1604877 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAACGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT32438 NZ_AP018923:1604543-1604908 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin