Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1994351..1994765 Replicon chromosome
Accession NZ_AP018922
Organism Staphylococcus aureus strain JMUB1273

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JMUB1273_RS10195 Protein ID WP_001065074.1
Coordinates 1994514..1994765 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMUB1273_RS14160 Protein ID WP_000028424.1
Coordinates 1994351..1994524 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMUB1273_RS10150 1990517..1990861 - 345 WP_000402904.1 hypothetical protein -
JMUB1273_RS10155 1990992..1991291 - 300 WP_000988336.1 HNH endonuclease -
JMUB1273_RS10160 1991523..1991939 - 417 WP_000590122.1 hypothetical protein -
JMUB1273_RS10165 1991967..1992167 - 201 WP_001794311.1 DUF1514 family protein -
JMUB1273_RS10170 1992167..1992817 - 651 WP_001005262.1 hypothetical protein -
JMUB1273_RS10175 1992976..1993125 - 150 WP_000595265.1 transcriptional activator RinB -
JMUB1273_RS10180 1993122..1993328 - 207 WP_000195810.1 DUF1381 domain-containing protein -
JMUB1273_RS10185 1993365..1993892 - 528 WP_117216380.1 dUTPase -
JMUB1273_RS14155 1993907..1994068 - 162 WP_172571785.1 hypothetical protein -
JMUB1273_RS10190 1994069..1994350 - 282 WP_000454994.1 hypothetical protein -
JMUB1273_RS14160 1994351..1994524 - 174 WP_000028424.1 hypothetical protein Antitoxin
JMUB1273_RS10195 1994514..1994765 - 252 WP_001065074.1 DUF1024 family protein Toxin
JMUB1273_RS10200 1994779..1995027 - 249 WP_117216382.1 hypothetical protein -
JMUB1273_RS10205 1995036..1995236 - 201 WP_000235326.1 hypothetical protein -
JMUB1273_RS10210 1995239..1995496 - 258 WP_000022720.1 DUF3310 domain-containing protein -
JMUB1273_RS10215 1995496..1995867 - 372 WP_115282698.1 hypothetical protein -
JMUB1273_RS10220 1995868..1996053 - 186 WP_001187242.1 DUF3113 family protein -
JMUB1273_RS10225 1996058..1996462 - 405 WP_000049784.1 DUF1064 domain-containing protein -
JMUB1273_RS10235 1996473..1996696 - 224 Protein_1893 DUF3269 family protein -
JMUB1273_RS10240 1996709..1996867 - 159 WP_015997089.1 hypothetical protein -
JMUB1273_RS10245 1996861..1997634 - 774 WP_117216985.1 ATP-binding protein -
JMUB1273_RS10250 1997644..1998414 - 771 WP_000190226.1 conserved phage C-terminal domain-containing protein -
JMUB1273_RS10255 1998460..1999119 + 660 WP_119267462.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / hlb / groEL 1967684..2020535 52851


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9513.41 Da        Isoelectric Point: 3.7128

>T32427 WP_001065074.1 NZ_AP018922:c1994765-1994514 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTSQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T32427 NZ_AP018922:c1994765-1994514 [Staphylococcus aureus]
ATGAATAATCGTGAACAAATTGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGAGTCAAGTTGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT32427 WP_000028424.1 NZ_AP018922:c1994524-1994351 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT32427 NZ_AP018922:c1994524-1994351 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References