Detailed information of TA system TA032424

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1971315..1971622
• Replicon: chromosome
• Accession: NZ_AP018922
• Organism: Staphylococcus aureus strain JMUB1273

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: JMUB1273_RS10055
• Protein ID: WP_072353918.1
• Coordinates: 1971446..1971622 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1971315..1971454 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMUB1273_RS10000	1966881..1967060	+	180	WP_000669789.1	hypothetical protein	-
JMUB1273_RS10010	1967371..1967631	+	261	WP_001791826.1	hypothetical protein	-
JMUB1273_RS10015	1967684..1968034	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
JMUB1273_RS10020	1968544..1968879	-	336	Protein_1850	SH3 domain-containing protein	-
JMUB1273_RS10035	1969531..1970022	-	492	WP_000920041.1	staphylokinase	-
JMUB1273_RS10040	1970213..1970968	-	756	WP_000861038.1	CHAP domain-containing protein	-
JMUB1273_RS10045	1970980..1971234	-	255	WP_000611512.1	phage holin	-
JMUB1273_RS10050	1971286..1971393	+	108	WP_001791821.1	hypothetical protein	-
-	1971315..1971454	+	140	NuclAT_0	-	Antitoxin
-	1971315..1971454	+	140	NuclAT_0	-	Antitoxin
-	1971315..1971454	+	140	NuclAT_0	-	Antitoxin
-	1971315..1971454	+	140	NuclAT_0	-	Antitoxin
JMUB1273_RS10055	1971446..1971622	-	177	WP_072353918.1	putative holin-like toxin	Toxin
JMUB1273_RS10060	1971765..1972139	-	375	WP_000340977.1	hypothetical protein	-
JMUB1273_RS10065	1972195..1972482	-	288	WP_001262620.1	hypothetical protein	-
JMUB1273_RS10070	1972528..1972680	-	153	WP_001000058.1	hypothetical protein	-
JMUB1273_RS10075	1972673..1976455	-	3783	WP_119267461.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1967684..2020535	52851

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T32424 WP_072353918.1 NZ_AP018922:c1971622-1971446 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T32424 NZ_AP018922:c1971622-1971446 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT32424 NZ_AP018922:1971315-1971454 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin