Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_31
Location 1608717..1609393 Replicon chromosome
Accession NZ_AP018920
Organism Pseudonocardia autotrophica strain NBRC 12743

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Pdca_RS07765 Protein ID WP_085916916.1
Coordinates 1609031..1609393 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Pdca_RS07760 Protein ID WP_085916917.1
Coordinates 1608717..1609034 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Pdca_RS36005 1604347..1604823 + 477 WP_179956585.1 transposase -
Pdca_RS07735 1604820..1605830 + 1011 WP_125911267.1 IS3 family transposase -
Pdca_RS07740 1606001..1607200 + 1200 WP_125911669.1 recombinase family protein -
Pdca_RS07750 1607945..1608256 - 312 WP_166665856.1 transposase -
Pdca_RS07760 1608717..1609034 - 318 WP_085916917.1 helix-turn-helix domain-containing protein Antitoxin
Pdca_RS07765 1609031..1609393 - 363 WP_085916916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Pdca_RS07770 1609493..1610344 - 852 WP_125911303.1 hypothetical protein -
Pdca_RS07775 1610390..1610965 - 576 WP_085916914.1 hypothetical protein -
Pdca_RS07780 1610970..1611359 - 390 WP_085916913.1 hypothetical protein -
Pdca_RS36010 1611605..1612081 + 477 WP_179956585.1 transposase -
Pdca_RS07790 1612078..1613088 + 1011 WP_125911267.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1596308..1621819 25511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13688.39 Da        Isoelectric Point: 5.2065

>T32418 WP_085916916.1 NZ_AP018920:c1609393-1609031 [Pseudonocardia autotrophica]
VVHEQWEVYIANEVRDWLDTLDPASHSRVVQAIDTLADTGPGLGRPLVDTIHGSTVANLKELRPGSVRILFAFDPWRSTI
LLVAGDKAGRWKTWYTEAIPLAEYRYERYLKERAHEEGES

Download         Length: 363 bp

>T32418 NZ_AP018920:c1609393-1609031 [Pseudonocardia autotrophica]
GTGGTCCACGAGCAGTGGGAGGTGTACATCGCCAACGAGGTACGCGACTGGCTCGACACACTCGACCCCGCCAGCCACAG
CCGGGTCGTGCAGGCCATCGACACCCTCGCCGACACCGGACCCGGCCTCGGACGCCCGCTGGTCGACACCATCCACGGAT
CCACCGTCGCCAACCTCAAGGAACTCCGCCCCGGCAGCGTGCGGATCCTGTTCGCCTTCGACCCGTGGCGATCCACGATC
CTGCTCGTCGCCGGGGACAAGGCCGGACGGTGGAAGACCTGGTACACCGAAGCGATACCGCTGGCCGAGTACCGATACGA
GCGCTATCTGAAGGAACGAGCCCACGAGGAGGGAGAGTCATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11361.90 Da        Isoelectric Point: 10.2920

>AT32418 WP_085916917.1 NZ_AP018920:c1609034-1608717 [Pseudonocardia autotrophica]
MSSHVAWNDIRAAHVERAGGEAAVDAGKRQMLAEVVGHRLAEIRRARGLTQQQVADRMGVTKGRISQIERGKVSGQDVLA
RYALALGGRLHQAIYFDDGDITAIA

Download         Length: 318 bp

>AT32418 NZ_AP018920:c1609034-1608717 [Pseudonocardia autotrophica]
ATGAGCAGCCACGTGGCCTGGAACGACATCCGCGCCGCCCACGTCGAGCGGGCCGGCGGTGAGGCCGCCGTCGACGCCGG
CAAGCGCCAGATGCTCGCCGAGGTCGTCGGCCACCGCCTTGCCGAGATCCGACGTGCTCGCGGTCTGACCCAGCAGCAGG
TCGCCGACCGCATGGGCGTCACCAAGGGCCGCATCTCCCAGATCGAACGCGGCAAGGTCTCTGGACAGGACGTCCTCGCC
CGCTACGCCCTCGCCCTCGGCGGCCGCCTGCACCAGGCCATCTACTTCGACGACGGCGACATCACCGCCATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References