Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1638583..1639194 Replicon chromosome
Accession NZ_AP018827
Organism Asticcacaulis excentricus strain M6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EM6_RS07615 Protein ID WP_126421581.1
Coordinates 1638583..1638864 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EM6_RS07620 Protein ID WP_126421583.1
Coordinates 1638895..1639194 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EM6_RS07600 1634672..1634995 - 324 WP_126422954.1 BrnA antitoxin family protein -
EM6_RS07605 1634961..1635284 - 324 Protein_1507 BrnT family toxin -
EM6_RS07610 1635316..1638177 - 2862 WP_126421580.1 DNA polymerase I -
EM6_RS07615 1638583..1638864 + 282 WP_126421581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EM6_RS07620 1638895..1639194 + 300 WP_126421583.1 HigA family addiction module antidote protein Antitoxin
EM6_RS07625 1639326..1639640 - 315 WP_197723621.1 DUF559 domain-containing protein -
EM6_RS07630 1639911..1640378 - 468 WP_126421585.1 lactoylglutathione lyase -
EM6_RS07635 1640477..1640689 - 213 WP_126421587.1 zinc-finger domain-containing protein -
EM6_RS07640 1640811..1641245 - 435 WP_126421589.1 OsmC family peroxiredoxin -
EM6_RS07645 1641487..1642248 + 762 WP_126421591.1 class II glutamine amidotransferase -
EM6_RS07650 1642282..1643253 + 972 WP_126421593.1 quinone oxidoreductase -
EM6_RS07655 1643250..1643834 - 585 WP_126421595.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(10-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10970.54 Da        Isoelectric Point: 9.4808

>T32408 WP_126421581.1 NZ_AP018827:1638583-1638864 [Asticcacaulis excentricus]
MIESFANRQTQQLFEGIAVKRMDAGLQKQALRRLIYLHAAISLDDLRVPPSNRLEALQGDRKGFYSIRVNDQWRIVFKWQ
DGKAYEVEFVDYH

Download         Length: 282 bp

>T32408 NZ_AP018827:1638583-1638864 [Asticcacaulis excentricus]
ATGATTGAAAGCTTCGCCAATCGTCAGACCCAGCAATTGTTTGAGGGCATCGCCGTCAAGCGCATGGATGCCGGTTTGCA
AAAGCAGGCACTTCGACGGTTGATCTACCTTCACGCCGCCATAAGCCTGGATGATCTGCGCGTTCCGCCGTCAAACCGGC
TGGAAGCCCTGCAAGGTGATCGCAAAGGCTTCTATTCGATCCGCGTCAATGACCAATGGCGCATTGTCTTCAAATGGCAG
GACGGCAAGGCCTATGAAGTCGAATTCGTGGACTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11154.03 Da        Isoelectric Point: 5.2053

>AT32408 WP_126421583.1 NZ_AP018827:1638895-1639194 [Asticcacaulis excentricus]
MTDYIDIDPPGVLLKEDFLDDLGIRPGTLAAAIKVDRAAIKAIIEGRRAITAEMALRLGLFLGTSPEFWLNLQKDYDLRK
AKRERFDELKAQIEPLKVA

Download         Length: 300 bp

>AT32408 NZ_AP018827:1638895-1639194 [Asticcacaulis excentricus]
ATGACGGACTATATCGACATCGACCCGCCGGGCGTCCTGCTGAAGGAAGACTTTCTGGACGATCTGGGCATCCGCCCCGG
CACGCTGGCGGCGGCCATAAAGGTGGATCGCGCGGCCATCAAGGCCATTATCGAAGGCCGCCGCGCCATCACGGCAGAAA
TGGCGCTGCGCCTGGGCCTGTTCCTCGGCACCAGCCCGGAGTTCTGGTTGAACCTGCAAAAGGACTACGATCTGCGCAAG
GCGAAGCGCGAACGGTTCGACGAGTTAAAAGCCCAGATCGAGCCGCTCAAGGTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References